TABLE 59-4.
Antimicrobial Therapy for Group A Streptococcal Pharyngitis
| DRUG | DOSE | DURATION |
|---|---|---|
| Oral Regimens | ||
| Penicillin V | Children: 250 mg bid or tid Adolescents and adults: 250 mg tid or qid or 500 mg bid |
10 days |
| Amoxicillin | 50 mg/kg once daily (maximum 1000 mg) Alternative: 25 mg/kg bid (maximum 500 mg) | 10 days |
| For Penicillin-Allergic Patients | ||
| Erythromycin | Varies with formulation | 10 days |
| First-generation cephalosporins | Varies with agent | 10 days |
| Intramuscular Regimens | ||
| Benzathine penicillin G | 600,000 units for patients <27 kg | 1 dose |
| 1.2 million units for patients ≥27 kg | 1 dose | |
| Mixtures of benzathine and procaine penicillin G | Varies with formulation | 1 dose |
Modified from Alcaide ML, Bisno AL. Pharyngitis and epiglottitis. Infect Dis Clin North Am. 2007;21:449-469, vii; with permission.