Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Sep 18:107–127. doi: 10.1016/B978-1-4160-3163-5.50013-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2008 Elsevier Inc. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Figure 7-2 — The juxtaglomerular apparatus and tubuloglomerular feedback (TGF). TGF is achieved because of the anatomy of the nephron and juxtaglomerular (JG) apparatus. TGF is a phenomenon that occurs when changes in tubular fluid concentrations of Na+, Cl-, and K+ are sensed by the macula densa, via the luminal Na+-K+-2Cl cotransporter. Increases or decreases in luminal uptake of these ions cause reciprocal changes in GFR by alterations in vascular tone, mainly in the afferent arteriole.

(From Guyton AC, Hall JE: The kidneys and body fluids. In Guyton AC, Hall JE (eds): Textbook of Medical Physiology (Fig 26.14, p. 292). Philadelphia, PA: WB Saunders, 2000.)