FIG. 13.2.

Hantavirus pulmonary syndrome (HPS). (A) Lung showing mononuclear interstitial pneumonitis and intraalveolar edema in a typical case of HPS. (B) Type II pneumocyte hyperplasia in the alveoli of an HPS patient as seen in patients with a prolonged clinical course. (C) Widespread immunostaining of hantaviral antigens in pulmonary microvasculature of an HPS patient. (D) Ultrastructural appearance of a typical granulofilamentous hantavirus inclusion within pulmonary capillary endothelium. (E) Spleen from a fatal case in which immunoblasts are seen in the periarteriolar sheath. Note prominent nucleoli and high nuclear-to-cytoplasmic ratio.

(D, courtesy of C.S. Goldsmith.)