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Varicella zoster virus (VZV) pneumonia. (A) Extensive necrosis and hemorrhage in a patient with fatal VZV pneumonia. (B) Amphophilic intranuclear inclusions (arrow) in VZV-infected cells at the edge of a necrotic focus. (C) Immunohistochemical staining of VZV antigens in the pulmonary parenchyma of patient with fatal VZV pneumonia. In the lungs, VZV infects many cell types, including respiratory epithelium, pneumocytes, endothelial cells, and fibroblasts.
