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. 2017 Feb 23:244–288. doi: 10.1016/B978-0-323-39308-9.00013-3

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FIG. 13.9 — Influenza. (A) Hemophagocytosis in a peribronchial lymph node in a patient with fatal influenza B. (B) Focus of myocyte necrosis accompanied by a mixed inflammatory cell infiltrate in the heart of a patient with fatal influenza B. (C) Diffuse alveolar damage in a patient with fatal avian influenza (H5N1) showing extensive hyaline membrane formation and congestion. (D) Influenza virus A (H5N1) antigens in the nucleus of a pneumocyte of a patient with fatal avian influenza. Unlike other influenza viruses that cause disease in humans, H5N1 preferentially infects alveolar epithelial cells, and causes relatively minimal pathology in the upper respiratory tract.