Table 2.
Mean 16-Year Developmental Test Scores By Randomization Group, Santiago Preventive Trial
| Outcome | N | Meana | Adjusted difference b | P-Valueb | |
|---|---|---|---|---|---|
| Iron-Fortified | Low-Iron | (95%CI) | |||
| IQ, Matrix Reasoning | 403 | 7.4 (2.3) | 7.2 (2.4) | 0.2 (−0.3, 0.6) | 0.47 |
| IQ, Verbal Similarities | 403 | 7.9 (2.1) | 8.2 (2.1) | −0.3 (−0.7, 0.1) | 0.12 |
| Spatial, Rey Copy | 275 c | 32.8 (4.1) | 33.4 (2.9) | −0.6 (−1.5, 0.2) | 0.16 |
| Spatial, Rey Memory | 275 c | 22.4 (6.1) | 24.0 (5.8) | −1.7 (−3.2, −0.3) | 0.02 |
| Arithmetic Achievement, WRAT | 403 | 82.3 (10.6) | 84.2 (11.7) | −2.4 (−4.5, −0.3) | 0.02 |
| Reading Achievement, Vocabulary | 384 | 21.5 (7.4) | 22.0 (7.3) | −0.9 (−2.3, 0.5) | 0.22 |
| Reading Achievement, Comprehension | 390 | 11.1 (4.5) | 12.0 (4.7) | −1.1 (−2.0, −0.2) | 0.02 |
| Visual Motor Integration, VMI | 401 | 85.0 (11.8) | 86.7 (9.9) | −1.7 (−3.8, 0.4) | 0.12 |
| Motor coordination, VMI supplemental | 401 | 88.9 (10.1) | 89.3 (10.2) | −0.3 (−2.3, 1.7) | 0.78 |
CI = confidence interval
a
Unadjusted mean (sd)
b
Test of difference in means adjusting for birthweight, gestational age, sex, maternal IQ, HOME environment, SES, average ml/day of formula intake, and age of assessment
c
Administration of Rey tasks was stopped approximately halfway through follow-up to reduce testing burden on participant.