Table 1.
Sample demographics.
| Cohort | Johns Hopkins Prospective PPD Cohort | Prospective Gene Expression PPD Cohort | FRAMES cohort |
|---|---|---|---|
| Total | 51 | 61 | 240 |
| PPD: Antenatal Euthymic | 10 | 1st:15; 3rd: 15 | 5 |
| PPD: Antenatal Depressed | 12 | 1st:14; 3rd: 18 | 0 |
| No PPD: Antenatal Euthymic | 22 | 1st:22; 3rd: 28 | 235 |
| No PPD: Antenatal Depressed | 7 | 0 | 0 |
| PPD Assessment | Prospective Clinical | Prospective HDRS, BD1, EPDSa | Prospective HDRS |
| Age | 30.68 ±6.32 | 33 | 32.7 ± 0.018 |
| 1st trimester | 9 | 51 | 0 |
| 2nd trimester | 22 | 0 | 0 |
| 3rd trimester | 20 | 61 | 0 |
| Postpartum | 0 | 0 | 240 |
| % Caucasian: African American: Other | 30:70:0% | 85:15:0% | 100:0:0% |
| Childhood Sexual Abuse | 19 | NA | NA |
| No Childhood Sexual Abuse | 29 | NA | NA |
| Procedures | |||
| Illumina HM450 beadchip | 51 | 0 | 0 |
| OXTR Targeted Pyrosequencing | 51 | 0 | 240 |
| Illumina HumanHT-12 V4.0 expression beadchip | 0 | 61 | 0 |
| Hormone Analysis | 31 | 0 | 0 |
a
Depression diagnoses as reported by Mehta et al. (2014) for the various time points were based on satisfying all of the following criteria: 1st trimester: Hamilton Depression Rating Scale (HDRS)>14, Edinburgh Postnatal Depression Scale (EPDS)>12, Beck Depression Inventory (BDI)>15; 3rd Trimester: HDRS>15, EPDS>15, BDI>12; 3 months postpartum: HDRS>14, EPDS>11, BDI>16.