. 2020 Apr 7;26(13):1501–1512. doi: 10.3748/wjg.v26.i13.1501

Table 4.

Multivariate analysis of prognostic factors for overall survival and recurrence-free survival

OS	Derivation cohort (n = 264)			Validation cohort (n = 263)
OS	HR	95%CI	P value	HR	95%CI	P value
Gender, F/M	0.847	0.58-1.216	0.367	-
Hepatolithiasis	1.073	0.677-1.699	0.765	-
Child-Pugh grade, A /B	0.775	0.38-1.583	0.485	-
Ascites	0.758	0.428-1.339	0.340	0.640	0.376-1.090	0.100
CA-199, ≥ 22/< 22	1.731	1.331-2.252	< 0.001^a	1.612	1.252-2.075	< 0.001^a
Tumor size	1.053	0.967-1.146	0.234	0.931	0.857-1.011	0.088
Tumor number, Multiple/Single	1.662	1.086-2.543	0.019^a	1.677	1.189-2.366	0.003^a
Tumor differentiation, Moderate-Poor/Well	-			7.927	1.083-58.02	0.042^a
Macrovascular invasion	1.199	0.781-1.843	0.407	-
Microvascular invasion	1.082	0.635-1.842	0.773	1.349	0.801-2.274	0.261
Liver capsule invasion	-			1.036	0.533-2.013	0.917
Node- positive	2.038	1.365-3.042	< 0.001^a	1.269	0.835-1.928	0.265
Perineural invasion	1.252	0.773-1.116	0.169	0.973	0.591-1.603	0.914
Cirrhosis	1.589	1.074-2.351	0.020^a	-
TNM stage, III/I-II	-			1.294	0.607-2.761	0.505
BCLC, B-C/0-A	0.627	0.364-1.078	0.091	1.307	0.813-2.101	0.269
NLR, > 2.62/≤ 2.62	1.357	0.912-2.017	0.132	1.287	0.897-1.846	0.170
PLR, > 103/≤ 103	1.141	0.776-1.679	0.502	1.094	0.778-1.539	0.604
GLR, > 33.7/≤ 33.7	1.620	1.066-2.462	0.024^a	1.466	1.033-2.142	0.048^a
RFS
Age	-			0.991	0.976-1.006	0.236
HBsAg	1.367	0.974-1.919	0.071	-
Ascites	0.763	0.473-1.230	0.266	0.621	0.382-1.010	0.055
CA-199, ≥ 22/< 22	1.406	1.128-1.752	0.002^a	1.319	1.050-1.656	0.017^a
Tumor size	1.073	0.994-1.158	0.072	0.975	0.906-1.050	0.501
Tumor number, Multiple/Single	1.434	0.998-2.060	0.051	1.613	1.172-2.219	0.003^a
Tumor differentiation, Moderate-Poor/Well	2.068	0.635-6.734	0.228	3.617	1.114-11.741	0.032^a
Macrovascular invasion	1.149	0.785-1.682	0.475	-
Microvascular invasion	1.643	1.031-2.618	0.037^a	1.607	0.986-2.618	0.057
Liver capsule invasion	-			0.778	0.428-1.417	0.413
Node-positive	1.859	1.272-2.716	0.001^a	0.972	0.664-1.421	0.882
TNM stage, III/I-II	0.892	0.559-1.328	0.572	1.524	0.778-2.988	0.220
BCLC, B-C/0-A	0.784	0.480-1.280	0.331	1.339	0.859-2.087	0.198
NLR, > 2.62/≤ 2.62	1.128	0.811-1.571	0.474	1.352	0.967-1.891	0.077
PLR, > 103/≤ 103	1.125	0.809-1.565	0.483	0.805	0.589-1.100	0.173
GLR, > 33.7/≤ 33.7	1.471	1.029-2.103	0.034^a	1.480	1.057-2.070	0.022^a

P < 0.05. OS: Overall survival; RFS: Recurrence-free survival; HBV: Hepatitis B virus; CA-199: Carbohydrate antigen-199; TNM: Tumor-node-metastasis; BCLC: Barcelona Clinic Liver Cancer; GLR: Gamma-glutamyltransferase to lymphocyte ratio; HR: Hazard ratio; CI: Confidence interval.