Table 1.

Studies included in Systematic Review.

Study	Study Type	Patient population	Antipsychotic type	Sample Type	DNA methylation approach
Abdolmaleky et. al [16]a	obs	Set 1 (saliva): 30 SCZ;30 HC;15 PR Set 2 (brain): 35 SCZ/BD;35 HC	NR	saliva and brain	gene-specific
Abdolmaleky et al. [17]	obs	35 SCZ; 35 BD; 35 HC	NR	brain	gene-specific
Abdolmaleky et al. [18]	obs	40 SCZ; 35 BD; 40 HC	NR	brain	gene-specific
Abdolmaleky et al. [19]	obs	Set 1 (brain): 35 SCZ/BD;35 HC Set 2 (saliva): 30 SCZ;20 BD;30 HC;20 UPR	NR	saliva and brain	gene-specific
Bönsch et al. [20]	obs	20 twin pairs discordant for SCZ; 8 pairs concordant for SCZ; 21 HC twin pairs; 21 psychiatric control twin pairs	AAP and TAP	blood	global and gene-specific
Bromberg et al. [21]	obs	28 SCZ; 26 HC	NR	blood	global
Burghardt et al. [22]b	obs	120 BD	AAP	bloodd	EWAS
Burghardt et al. [23]c	obs	Discovery Set: 96 SCZ; Validated Set: 166 SCZ	AAP	bloodd	EWAS
Burghardt et al.[24]	obs	30 BD	AAP	skeletal muscle	gene-specific
Burghardt et al. [25]	obs	115 BD	AAP	blood	global
Burghardt et al. [26]	obs	133 SCZ	AAP and TAP	blood	global
Cheng et al. [27]	obs and prosp	60 SCZ; 30 HC	risperidone	blood	gene-specific
D’Addario et al.[28]	obs	24 MDD;24 BD I; 24 BD II; 25 SCZ; 34 HC	AAP and TAP	blood	gene-specific
Ellingrod et al. [29]	prosp	35 SCZ	AAP and TAP	blood	global
Houtepen et al. [30]	obs	172 BD	olanzapine and quetiapine	bloodd	EWAS and gene-specific
Kinoshita et al. [31]	prosp	21 SCZ	olanzapine	blood	EWAS
Li et al. [32]	obs	92 SCZ; 99 BD; 92 HC	AAP and TAP	blood	global
Lott et al. [33]	obs	85 SCZ	NR	blood	gene-specific
Melas et al. [34]	obs	177 SCZ; 171 HC	AAP and TAP	blood	global and gene-specific
Mill et al. [35]	obs	35 SZ; 35 BD; 35 HC	NR	brain	EWAS
Miura et al. [36]	prosp	34 SCZ	risperidone	blood	gene-specific
Moons et al. [37]	obs	438 SCZ	AAP and TAP	blood	gene-specific
Nour El Huda et al. [38]	obs	138 SCZ; 132 HC	AAP and TAP	blood	gene-specific
Rukova et al. [39]	prosp	20 SCZ; 220 HC	NR	blood	EWAS
Shi et al. [40]	prosp	288 SCZ	risperidone	blood	gene-specific
Swathy et al. [41]	obs	184 SCZ; 330 HC	NR	blood	global
Tang et al. [42]	prosp	82 SCZ	AAP and TAP	blood	gene-specific
Venugopal et al. [43]	prosp	47 SCZ; 47 HC	AAP	blood	gene-specific
Zong et al. [44]	obs	279 SCZ; 265 HC	AAP and TAP	blood	gene-specific

Details of 29 studies included in the systematic review including study design, type of antipsychotic within study, sample type for DNA methylation analysis, and overall DNA methylation strategy. Abbreviations: AAP = atypical antipsychotic; BD = bipolar disorder; EWAS = Epigenome-Wide Association Study; HC = healthy control; MDD = major depressive disorder; NR = not reported; obs = observational; PR = primary relative; pros =prospective; scz = schizophrenia; TAP = typical antipsychotic; UPR = unaffected primary relative

^aAbdolmakey et al. studies (references 16–19) did not state if patient overlap was present for included samples

^bBurghardt et al. references 22 and 25 had patient overlap

^cBurghardt et al. references 23 and 26 had patient overlap

^dControlled for cell type composition