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. 2020 Mar 13;12(3):e7257. doi: 10.7759/cureus.7257

Table 1. Summary of all included studies in this systematic review.

Authors/Study Design Year Main Conclusions
Endo M, et al. Brazil (In-vivo study) 2013 The great majority of taxa found in post-treatment samples were Gram-positive bacteria
Pereira RS, et al. Brazil (In-vivo study) 2017 Further studies are necessary to elucidate the role of these microorganisms in endodontic treatment failures.
Rôças IN, et al. Brazil (In-vivo study) 2012 The findings call into question the status of E. faecalis as the main pathogen and suggest that other species can be candidate pathogens associated with persistent/secondary endodontic infections.
Schirrmeister JF, et al. Germany (In-vivo study) 2009 In all teeth with Parvimonas micra and Dialister invisus, F. nucleatum and S. moorei were found. Moreover, members of additional different genera were detected delivering bacterial compositions that have been not described yet.
Jhajharia K, et al. Malaysia (Review) 2015 The most common endodontic infection is caused by the surface-associated growth of microorganisms.
Narayanan LL, Vaishnavi C. India (Review) 2010 The well-filled root canal offers the microbial flora a small, dry, nutritionally limited space. Thus, we should obtain a better understanding of the characteristics and properties of bacteria and their biofilms along with the environmental changes, to enhance success.
Del Fabbro M, et al. Italy (Review) 2014 The picture emerging from this review is that extraradicular infection is likely a multifactorial disease that requires further systematic investigation using standardized techniques.
Ran S, et al. China (In-vitro study) 2015 A number of the regulated genes may be useful candidates for the development of new therapeutic approaches for the treatment of E.faecalis infections.
OH Donmez, et al. Turkey (In-vitro study) 2019 The data of the induced and non-induced fabclavine promoter exchange mutants clearly show that fabclavine derivatives are bioactive compounds responsible for the bactericidal effect.
Lee D, et al. Korea (In-vitro study) 2019 These results suggest that phage HEf13 has the characteristics of a lytic phage and is a potential therapeutic agent for the treatment or prevention of E. faecalis-associated infectious diseases.
Ghorbanzadeh A, et al. Iran (Ex-vivo study) 2020 All three disinfection methods were effective for the partial elimination of E. faecalis biofilm. But conventional chemomechanical debridement + light-activated disinfection (CCMD + LAD) was significantly more efficacious in decreasing both mature and immature biofilms.