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. 2020 Jan 15;16(2):335–343. doi: 10.1007/s12015-020-09953-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Diurnal changes in the numbers of circulating MSCs, EPCs, and VSELs in mice after inhibition of ATP release in a pannexin 1-dependent manner or after exposure to MCC950, a specific inhibitor of the Nlrp3 inflammasome. The highest number of stem cells circulating in PB was observed in mice at ZT5 (11 AM). The numbers of these cells were regulated in a pannexin 1- and Nlrp3 inflammasome-dependent manner. Data are pooled from two independent experiments (n = 6 mice each). *p ≤ 0.05. All parameters studied in this work were measured at predefined ZT points only