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. 2020 Mar 31;17:31–46. doi: 10.1016/j.omto.2020.03.005

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

PC Inhibitor Triggers Molecular Changes in Protein Profiles of C6 Spheroid and Mixed C6/NR8383 Spheroids

(A and B) C6 spheroids (A) and mixed C6/NR8383 spheroids (B) were treated with 100 μM PC inhibitor or with DMSO (control) and lysed before FASP and LC-MS/MS analysis. MaxQuant and Perseus software were used for the statistical analysis, and heatmaps were generated to show proteins that were significantly different between treated and untreated spheroids. Different clusters are highlighted. Biological process for clusters of spheroids C6 and C6/NR8383. The analysis was performed with FunRich.