. 2020 Mar 31;17:31–46. doi: 10.1016/j.omto.2020.03.005

Table 1.

PC Inhibitor Is More Efficient than Temozolomide (TMZ) on the Spheroid Invasion Decrease

	Mean of the Percentage of Invasion after 4 Days of Stimulation
	100 μM PC Inhibitor	600 μM TMZ
C6 spheroids	47.66% ± 16.41%	74.37% ± 9.06%
C6 spheroids	p < 0.0001	p = 0.0037
Mixed C6/macrophages spheroids	61.62% ± 6.41%	73.84% ± 5.49%
Mixed C6/macrophages spheroids	p < 0.0001	p < 0.0001

C6 and mixed C6/NR8383 spheroids were incubated with 100 μM PC inhibitor or with 600 μM TMZ. All images were acquired with an inverted light microscope at ×5 original magnification. The percentages of spheroids invasion are shown. All results are representative of three independent experiments. Significant differences were identified using a Tukey’s multiple comparisons test. PC, proprotein convertase; TMZ, temozolomide.