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. 2020 Apr 3;10:387. doi: 10.3389/fonc.2020.00387

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Copyright © 2020 Pan, Yang, He, Gao, Jiang, Chen and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression of miRNAs in CSF from discover cohort. (A) The overlapping miRNAs differentially expressed between two comparison models (LMs, n = 10; BMs, n = 5; NCs, n = 5); (B) Heatmap of differentially expressed CSF miRNAs analyzed by microarray between LMs (n = 10) and non-LMs controls (BMs, n = 5; NCs, n = 5); (C) Heatmap of differentially expressed miRNAs analyzed by microarray in paired CSF samples from 6 LM patients at diagnosis and after initial LM-directed therapy. Fold change ≥2 or ≤0.5 was regarded as statistically significant. CSF, cerebrospinal fluid; LMs, leptomeningeal metastases; BMs, brain metastases; NCs, non-cancers.