Fig. 7.

Supplementation with compounds impacting on PDH. NRVM cultures were supplemented with the indicated concentrations of lipoic acid, thiamine and DCA, and, after 7 days of frataxin depletion, mitochondria were stained with TMRM (A, C and E). The amount of enlarged mitochondria was measured with ImageJ (B, D and F). Graphs represent the relative number of enlarged mitochondria relative to non-treated FXN deficient cells values. Scale bar = 30μm.