Table IV.
Maximum Concentrations (Cmax), Time to Maximum Concentrations (Tmax) and Detection Windows for Cannabinoids in Urine Following Administration of Oral and Vaporized CBD and CBD-dominant Cannabis
| Subject ID# | CBD Cmax (ng/mL) |
CBD Tmax (h) |
CBD dose excreted (%) | CBD first detected (h) |
CBD last detected (h) |
∆9-THC-COOH Cmax (ng/mL) |
∆9-THC-COOH Tmax (h) |
∆9-THC-COOH first detected (h) |
∆9-THC-COOH last detected (h) |
|---|---|---|---|---|---|---|---|---|---|
| Placebo | |||||||||
| 038 | 14.1 | 5 | N/A | BL | 103 | 2 | 5 | BL | 5 |
| 053 | 3.1 | 1.5 | N/A | BL | 97 | ND | ND | ND | ND |
| 054 | 0.4 | 2 | N/A | 1.5 | 3 | ND | ND | ND | ND |
| 063 | 2.3 | 48 | N/A | BL | 73 | ND | ND | ND | ND |
| 066 | 2 | 2 | N/A | 1.5 | 52 | ND | ND | ND | ND |
| 068 | 4.7 | 32 | N/A | BL | 96 | 2.2 | BL | BL | BL |
| Mean (total) | 4.4 | 15.1 | 0.7 | 2.5 | |||||
| 100-mg oral CBD | |||||||||
| 038 | 2,941 | 9 | 1.0 | BL | 98 | ND | ND | ND | ND |
| 053 | 210.2 | 2 | 0.03 | 1.5 | 48 | ND | ND | ND | ND |
| 054 | 496.1 | 4 | 0.22 | BL | 103 | 2.9 | 1.5 | BL | 103 |
| 063 | 214.6 | 3 | 0.12 | 1.5 | 74 | ND | ND | ND | ND |
| 066 | 526 | 5 | 0.22 | 1.5 | 96 | ND | ND | ND | ND |
| 068 | 269.6 | 9 | 0.23 | BL | 96 | 1.3 | BL | BL | 11 |
| Mean (total) | 776.3 | 5.3 | 0.30 | 0.7 | 0.8 | ||||
| 100-mg vaporized CBD | |||||||||
| 038 | 631.1 | 0.5 | 0.26 | 0.5 | 95 | 1.2 | 3 | 3 | 3 |
| 053 | 15.3 | 1 | 0.003 | 1 | 23 | ND | ND | ND | ND |
| 054 | 79.3 | 1 | 0.05 | 0.5 | 102 | ND | ND | ND | ND |
| 063 | 248.7 | 1 | 0.09 | BL | 97 | ND | ND | ND | ND |
| 066 | 394.2 | 0.5 | 0.05 | 0.5 | 72 | ND | ND | ND | ND |
| 068 | 194.5 | 0.5 | 0.17 | BL | 95 | 2 | 96 | BL | 95 |
| Mean (total) | 260.5 | 0.75 | 0.10 | 0.5 | 54 | ||||
| Vaporized cannabis (100-mg CBD/3.7-mg THC) | |||||||||
| 038 | 539.1 | 2 | 0.28 | BL | 94 | 29.9 | 4 | 1 | 94 |
| 053 | 126.1 | 1 | 0.01 | 1 | 97 | 1.2 | 23 | 23 | 23 |
| 054 | 232.8 | 2 | 0.11 | BL | 94 | 7.3 | 8 | 2 | 94 |
| 063 | 195.9 | 0.5 | 0.08 | 0.5 | 95 | 1.6 | 23 | 1 | 23 |
| 066 | 351 | 1 | 0.06 | 0.5 | 95 | 4.7 | 3 | BL | 16 |
| 068 | 399 | 0.5 | 0.17 | 0.5 | 95 | 23.2 | 4 | 0.5 | 95 |
| Mean (total) | 307.3 | 1.2 | 0.12 | 11.3 | 10.8 | ||||
Note: N/A = not applicable for that analyte; ND = analyte not detected for that participant/condition; BL = baseline. Midpoint time value used for pooled specimens. Tmax and time to first and last detection are relative to oral dosing for 100-mg oral CBD and relative to dose inhalation for 100-mg vaporized CBD and CBD-dominant cannabis. Note: 038, 066 and 068 were males; 053, 054 and 063 were females.