Table V.
Comparisons of IA Responses to Confirmation Analyses (LC–MS-MS) in Urine Specimens Following Administration of Oral and Vaporized CBD and CBD-dominant Cannabis
| Urine ∆9-THCCOOH IA (cutoff = 20 ng/mL) vs ∆9-THCCOOH LC–MS-MS (confirmation = 15 ng/mL) |
Urine ∆9-THCCOOH IA (cutoff = 50 ng/mL) vs ∆9-THCCOOH LC–MS-MS (confirmation = 15 ng/mL) |
Urine ∆9-THCCOOH IA (cutoff = 100 ng/mL) vs ∆9-THCCOOH LC–MS-MS (confirmation = 15 ng/mL) |
|
|---|---|---|---|
| 100-mg oral CBD | |||
| #True positive (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| #True negative (%) | 109 (99.1) | 110 (100.0) | 110 (100.0) |
| #False positive (%) | 1 (0.9) | 0 (0.0) | 0 (0.0) |
| #False negative (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Sensitivity (%) | 0 | 0 | 0 |
| Specificity (%) | 99.1 | 100.0 | 100.0 |
| Agreement (%) | 99.1 | 100.0 | 100.0 |
| 100-mg Vaporized CBD | |||
| #True positive (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| #True negative (%) | 108 (100.0) | 108 (100.0) | 108 (100.0) |
| #False positive (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| #False negative (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Sensitivity (%) | 0 | 0 | 0 |
| Specificity (%) | 100.0 | 100.0 | 100.0 |
| Agreement (%) | 100.0 | 100.0 | 100.0 |
| Vaporized cannabis (100-mg CBD/3.7-mg THC) | |||
| #True positive (%) | 4 (3.7) | 2 (1.9) | 0 (0.0) |
| #True negative (%) | 99 (91.7) | 104 (96.3) | 104 (96.3) |
| #False positive (%) | 5 (4.6) | 0 (0.0) | 0 (0.0) |
| #False negative (%) | 0 (0.0) | 2 (1.9) | 4 (3.7) |
| Sensitivity (%) | 100.0 | 50.0 | 0 |
| Specificity (%) | 95.2 | 100.0 | 100.0 |
| Agreement (%) | 95.4 | 98.1 | 96.3 |