Table 2.
Wisc-1 tg33-specific titers in CWD lineages generated in deer expressing PrPC polymorphisms Ser-96 and His-95
| Dilution factora | No. of positive mice/no. of mice inoculatedb (incubation period range; days post-inoculation) | |||
|---|---|---|---|---|
| −2 | 8/8 (306–354) | 6/6 (302–349) | 3/3 (332–378) | 4/4 (350–414) |
| −3 | 8/8 (346–389) | 6/6 (346–364) | 7/7 (332–417) | 4/4 (421–488) |
| −4 | 8/8 (375–427) | 6/6 (381–485) | 8/8 (354–458) | 7/7 (533–663) |
| −5 | 8/8 (374–482) | 6/6 (403–546) | 9/9 (436–514) | 3/12 (505–659) |
| −6 | 8/8 (391–550) | 6/6 (462–578) | 8/8 (555–633) | 1/11 (673) |
| −7 | 4/8 (389–570) | 1/10 (605) | 4/6 (515–612) | 1/8 (663) |
| Wisc-1 CWD lineages (P0) | WT/WT | S96/WT | H95/WT | H95/S96 |
| Log i.c. ID50·μl−1 | 6.944 | 6.489 | 6.696 | 4.966 |
| Log i.c. ID50·μl−1 | 8.4 | 8.0 | 8.2 | 6.4 |
a Serial 10-fold dilutions of 10% BH w/v.
b Intercurrent disease or found dead was not included.