Figure 5.

Proposed model of the relationship between cortical actin, LYVE-1 dynamics, and HA binding in the lymphatic endothelial cell plasma membrane. Changes in the cytoskeletal actin from its native polymerized state (A) to a depolymerized state (B) within LECs increase the lateral mobility of LYVE-1, enabling multimolecular HA complexes such as those in the surface glycocalyx of lymph-migrating leukocytes to induce higher-order clustering of the receptor and harness the binding avidity required for pro-adhesive interactions (B).