Table 3.

MR Estimates Between Circulating Levels of IGF1 and IGFBP3 and Risk of Colorectal Cancer (n = 52,865 Colorectal Cancer Cases and n = 46,287 Controls)

	MR
	Likelihood-based approach	Weighted median approach	MR-Egger test
	OR (95% CI) per 1-SD increment	OR (95% CI) per 1-SD increment	OR (95% CI) per 1-SD increment
IGF1
Colorectal cancer
Both sexes	1.08 (1.03–1.12)	1.12 (1.04–1.20)	1.11 (0.98–1.27)
Men	1.11 (1.05–1.17)	1.07 (0.97–1.18)	1.18 (1.00–1.38)
Women	1.05 (0.99–1.11)	1.07 (0.97–1.18)	1.06 (0.89–1.25)
Colon cancer
Both sexes	1.06 (1.01–1.11)	1.12 (1.03–1.23)	1.14 (0.98–1.32)
Proximal colon cancer
Both sexes	1.04 (0.97–1.11)	1.08 (0.97–1.21)	1.02 (0.84–1.23)
Distal colon cancer
Both sexes	1.07 (1.00–1.14)	1.10 (0.98–1.23)	1.26 (1.05–1.50)
Rectal cancer
Both sexes	1.06 (1.00–1.14)	1.01 (0.90–1.13)	1.09 (0.91–1.30)
IGFBP3
Colorectal cancer
Both sexes	1.12 (1.06–1.18)	1.14 (1.07–1.20)	1.18 (1.07–1.31)
Men	1.12 (1.04–1.21)	1.13 (1.04–1.22)	1.14 (0.98–1.34)
Women	1.12 (1.04–1.21)	1.13 (1.04–1.22)	1.25 (1.18–1.32)
Colon cancer
Both sexes	1.11 (1.04–1.19)	1.13 (1.05–1.21)	1.27 (1.16–1.38)
Proximal colon cancer
Both sexes	1.12 (1.03–1.22)	1.12 (1.02–1.23)	1.25 (1.21–1.29)
Distal colon cancer
Both sexes	1.10 (1.01–1.20)	1.13 (1.03–1.24)	1.29 (1.01–1.65)
Rectal cancer
Both sexes	1.12 (1.04–1.22)	1.14 (1.05–1.25)	1.18 (1.01–1.39)