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. 2020 Apr;158(5):1300–1312.e20. doi: 10.1053/j.gastro.2019.12.020

Supplementary Table 2.

Association Parameters of Instrumental SNPs Used in the IGF1 and IGFBP3 Genetic Instruments

SNP Chr Position Genea Effect allele Other allele Association parameters for the exposure
 Association parameters for colorectal cancer
 Association parameters for colorectal cancer men
 Association parameters for colorectal cancer women
 Association parameters for colon cancer
 Association parameters for proximal colon cancer
 Association parameters for distal colon cancer
 Association parameters for rectal cancer
Effect SE Effect SE Effect SE Effect SE Effect SE Effect SE Effect SE Effect SE
IGF1 - n SNPs = 413
rs903908 1 2,202,967 SKI T C −0.016 0.003 −0.006 0.009 −0.014 0.013 0.003 0.013 −0.016 0.011 −0.006 0.014 −0.023 0.014 0.016 0.014
rs17393144 1 9,210,262 MIR34A G A −0.016 0.003 0.006 0.010 0.019 0.013 −0.007 0.014 0.005 0.011 0.012 0.015 −0.002 0.015 −0.005 0.015
rs112436634 1 10,637,709 PEX14 C T −0.016 0.003 0.001 0.009 −0.014 0.013 0.014 0.013 −0.002 0.011 −0.014 0.015 0.018 0.015 0.017 0.015
rs17037452 1 11,895,675 CLCN6 A G 0.023 0.003 0.000 0.012 −0.011 0.017 0.011 0.018 0.000 0.015 0.029 0.019 −0.029 0.019 −0.003 0.019
rs36086195 1 16,510,894 ARHGEF19−AS1 T C −0.019 0.003 0.018 0.009 0.012 0.013 0.028 0.013 0.020 0.011 0.003 0.014 0.043 0.014 0.010 0.014
rs12723255 1 21,233,570 EIF4G3 T C −0.017 0.003 0.002 0.009 0.004 0.013 0.001 0.013 0.003 0.011 −0.002 0.014 0.008 0.014 0.010 0.014
rs6701954 1 22,022,176 USP48 T G 0.014 0.003 0.005 0.009 0.007 0.012 −0.001 0.013 −0.008 0.011 0.007 0.014 −0.022 0.014 0.014 0.014
rs76914895 1 23,292,603 LACTBL1 T C −0.027 0.005 0.046 0.019 0.054 0.026 0.038 0.027 0.030 0.022 0.026 0.029 0.054 0.030 0.093 0.029
rs2075995 1 23,847,464 E2F2 A C −0.014 0.003 0.003 0.009 0.011 0.012 −0.003 0.013 0.008 0.011 −0.004 0.014 0.024 0.014 0.014 0.014
rs2802330 1 26,466,831 PDIK1L A G −0.031 0.003 0.003 0.012 −0.001 0.016 0.004 0.016 0.011 0.014 0.025 0.018 −0.009 0.018 −0.004 0.018
rs17360994 1 27,278,573 KDF1 C T −0.042 0.005 −0.012 0.017 −0.003 0.023 −0.023 0.024 −0.006 0.020 −0.012 0.026 0.022 0.026 −0.005 0.026
rs569356 1 29,136,686 OPRD1 A G −0.027 0.004 0.007 0.013 −0.016 0.018 0.035 0.019 0.005 0.016 0.019 0.020 −0.001 0.021 0.012 0.020
rs3131646 1 40,383,552 MYCL G T 0.016 0.003 −0.006 0.010 −0.006 0.013 −0.008 0.014 −0.013 0.012 −0.029 0.015 0.002 0.015 0.002 0.015
rs61780439 1 41,490,177 SLFNL1−AS1 G A 0.021 0.003 0.004 0.011 0.012 0.015 −0.001 0.015 −0.011 0.013 −0.013 0.017 −0.007 0.017 0.013 0.017
rs2819336 1 44,015,809 PTPRF C T −0.027 0.003 −0.004 0.009 −0.003 0.013 −0.006 0.013 −0.007 0.011 −0.019 0.014 0.001 0.015 0.008 0.014
rs7539178 1 65,383,002 JAK1 A C −0.026 0.004 −0.024 0.013 −0.026 0.018 −0.023 0.018 −0.036 0.016 −0.047 0.020 −0.008 0.021 −0.015 0.020
rs1046011 1 65,898,996 LEPR / LEPROT C T −0.021 0.003 0.011 0.010 0.006 0.014 0.017 0.014 0.005 0.012 −0.001 0.015 0.014 0.015 0.015 0.015
rs1430753 1 68,692,642 WLS G A −0.021 0.003 −0.011 0.011 −0.012 0.016 −0.010 0.016 −0.007 0.013 0.000 0.017 −0.020 0.018 −0.041 0.017
rs165316 1 91,533,297 RPL5P6 A G −0.073 0.003 −0.018 0.011 −0.045 0.015 0.009 0.016 −0.037 0.013 −0.035 0.017 −0.033 0.017 0.006 0.017
rs1825813 1 92,708,973 C1orf146 G A −0.023 0.003 −0.027 0.011 −0.044 0.016 −0.009 0.016 −0.037 0.013 −0.034 0.017 −0.040 0.018 −0.019 0.017
rs599839 1 109,822,166 PSRC1/CELSR2 A G −0.031 0.003 0.006 0.011 0.013 0.015 −0.002 0.015 0.009 0.013 −0.004 0.016 0.022 0.017 0.029 0.016
rs45505697 1 153,651,058 NPR1 C A 0.030 0.005 0.011 0.020 −0.009 0.028 0.037 0.029 0.021 0.024 0.015 0.031 0.023 0.032 0.022 0.031
rs1127313 1 154,556,425 ADAR G A 0.024 0.003 0.009 0.009 0.007 0.012 0.013 0.013 0.007 0.011 −0.001 0.014 0.017 0.014 0.019 0.014
rs77369503 1 163,027,266 RGS4 G A 0.045 0.007 −0.004 0.028 −0.002 0.038 −0.013 0.041 −0.027 0.033 −0.048 0.042 −0.051 0.043 0.012 0.042
rs75681856 1 174,916,323 RABGAP1L C T −0.023 0.004 0.006 0.013 0.016 0.019 −0.007 0.019 −0.004 0.016 −0.010 0.021 −0.007 0.021 0.015 0.021
rs12749024 1 176,522,365 PAPPA2 C T −0.075 0.004 −0.008 0.013 −0.019 0.018 0.000 0.018 −0.011 0.015 −0.008 0.020 −0.009 0.020 −0.013 0.020
rs10913351 1 177,447,742 AL122019.1 G A −0.032 0.005 0.021 0.018 0.028 0.026 0.017 0.026 0.020 0.022 0.022 0.028 0.023 0.029 0.004 0.028
rs11577063 1 179,341,999 AXDND1 G T −0.020 0.003 −0.011 0.011 0.007 0.015 −0.031 0.015 −0.011 0.013 −0.025 0.016 −0.002 0.017 −0.020 0.016
rs143885630 1 183,482,785 SMG7 G A 0.030 0.004 −0.013 0.014 −0.013 0.019 −0.008 0.020 −0.014 0.017 −0.045 0.022 0.016 0.022 0.019 0.022
rs940400 1 200,269,134 LINC00862 C A 0.025 0.004 0.012 0.014 0.016 0.019 0.007 0.020 0.023 0.017 0.001 0.021 0.014 0.022 −0.016 0.021
rs7545345 1 205,690,941 NUCKS1 T C −0.026 0.004 0.000 0.013 0.007 0.019 −0.007 0.019 0.002 0.016 −0.017 0.021 0.016 0.021 −0.013 0.021
rs2724373 1 207,999,200 C1orf132 C T 0.019 0.003 −0.014 0.009 −0.003 0.013 −0.030 0.013 −0.024 0.011 −0.024 0.014 −0.022 0.015 −0.011 0.014
rs10779509 1 209,728,370 AL023754.1 T C −0.014 0.003 −0.012 0.009 −0.024 0.013 0.000 0.013 −0.016 0.011 −0.013 0.014 −0.021 0.014 −0.017 0.014
rs340837 1 214,162,734 PROX1 T G −0.021 0.003 −0.025 0.009 −0.034 0.012 −0.011 0.013 −0.032 0.011 −0.029 0.014 −0.029 0.014 −0.019 0.014
rs12141189 1 221,053,545 HLX C T −0.045 0.003 0.023 0.010 0.015 0.015 0.033 0.015 0.031 0.013 0.033 0.016 0.027 0.017 0.000 0.016
rs4306136 1 221,608,720 AL360013.2 A G 0.017 0.003 0.014 0.009 0.001 0.013 0.029 0.013 0.010 0.011 0.026 0.014 0.001 0.014 0.022 0.014
rs708108 1 228,189,855 WNT3A C T −0.015 0.003 −0.007 0.009 −0.009 0.013 −0.009 0.013 −0.007 0.011 −0.013 0.014 −0.001 0.014 −0.011 0.014
rs684818 1 234,854,779 AL160408.6 T C 0.024 0.003 0.030 0.009 0.028 0.012 0.029 0.013 0.021 0.011 0.019 0.014 0.027 0.014 0.038 0.014
rs7517340 1 243,710,190 AKT3 C T 0.035 0.003 −0.001 0.011 0.018 0.016 −0.020 0.016 −0.009 0.014 −0.011 0.018 0.003 0.018 0.013 0.018
rs35135518 2 16,120,506 RN7SL104P T C 0.029 0.004 −0.006 0.015 −0.006 0.020 −0.006 0.021 0.004 0.018 −0.002 0.024 0.001 0.024 −0.004 0.024
rs12710648 2 17,989,500 SMC6 A G 0.017 0.003 −0.003 0.009 −0.003 0.013 0.000 0.013 −0.002 0.011 0.015 0.014 −0.015 0.014 0.004 0.014
rs6760135 2 26,088,769 ASXL2 C T −0.050 0.003 −0.002 0.011 0.001 0.016 −0.005 0.016 −0.010 0.013 −0.006 0.017 −0.015 0.017 0.004 0.017
rs1260326 2 27,730,940 GCKR C T 0.063 0.003 0.036 0.009 0.043 0.013 0.029 0.013 0.035 0.011 0.019 0.014 0.052 0.014 0.034 0.014
rs11677980 2 30,522,137 LBH A G −0.015 0.003 −0.014 0.010 0.002 0.014 −0.031 0.014 −0.011 0.012 −0.006 0.015 −0.014 0.015 −0.017 0.015
rs7574340 2 40,621,239 SLC8A1 C T −0.017 0.003 0.012 0.009 0.025 0.013 0.000 0.014 0.019 0.012 0.021 0.015 0.016 0.015 0.005 0.015
rs6544549 2 42,693,056 KCNG3 T C 0.024 0.004 0.026 0.013 0.022 0.018 0.027 0.018 0.025 0.016 0.041 0.020 0.007 0.020 0.039 0.020
rs62136965 2 44,347,953 snRNA T C −0.037 0.006 0.022 0.022 0.001 0.030 0.051 0.032 0.031 0.026 0.025 0.034 0.035 0.034 −0.012 0.033
rs3791679 2 56,096,892 EFEMP1 A G −0.018 0.003 0.020 0.010 0.031 0.014 0.011 0.015 0.021 0.012 0.013 0.016 0.032 0.016 0.023 0.016
rs12471768 2 64,928,603 SERTAD2 C T 0.022 0.003 −0.012 0.010 −0.004 0.014 −0.020 0.014 −0.021 0.012 −0.038 0.015 0.000 0.015 0.000 0.015
rs702878 2 65,702,609 AC007389.1 A G 0.014 0.003 0.011 0.009 0.020 0.012 0.003 0.013 0.014 0.011 0.009 0.014 0.009 0.014 0.015 0.014
rs35641591 2 70,323,994 PCBP1−AS1 C T 0.050 0.006 0.070 0.027 0.031 0.037 0.103 0.038 0.040 0.032 0.032 0.041 0.039 0.043 0.071 0.042
rs6749680 2 73,685,852 ALMS1 A G 0.015 0.003 −0.001 0.009 −0.001 0.013 −0.003 0.013 −0.004 0.011 0.009 0.014 −0.016 0.014 −0.004 0.014
rs73954943 2 111,890,432 BCL2L11 G A −0.031 0.005 −0.032 0.018 −0.069 0.025 −0.003 0.025 −0.036 0.022 −0.044 0.028 −0.047 0.029 −0.041 0.029
rs7578633 2 113,978,650 PAX8 C T −0.018 0.003 −0.017 0.009 −0.013 0.013 −0.021 0.013 −0.014 0.011 −0.035 0.014 −0.003 0.014 −0.021 0.014
rs17050272 2 121,306,440 AC073257.2 G A 0.024 0.003 0.010 0.009 0.012 0.013 0.007 0.013 0.003 0.011 −0.010 0.014 0.018 0.014 0.011 0.014
rs58387407 2 152,924,773 CACNB4 A G −0.018 0.003 −0.002 0.011 0.013 0.015 −0.017 0.016 −0.018 0.013 −0.022 0.017 −0.023 0.017 0.017 0.017
rs2674492 2 172,422,338 CYBRD1 G A −0.014 0.003 0.027 0.009 0.029 0.013 0.022 0.013 0.028 0.011 0.033 0.014 0.029 0.015 0.028 0.014
rs17400325 2 178,565,913 PDE11A C T 0.054 0.006 0.004 0.023 −0.004 0.031 0.011 0.033 0.016 0.027 0.003 0.035 0.052 0.035 0.011 0.034
rs6435156 2 203,425,475 BMPR2 C T 0.024 0.003 0.015 0.010 0.013 0.014 0.017 0.015 0.013 0.012 0.015 0.016 0.020 0.016 0.025 0.016
rs1427676 2 204,741,166 CTLA4 T C 0.015 0.003 0.025 0.009 0.026 0.013 0.022 0.013 0.025 0.011 0.008 0.015 0.035 0.015 0.030 0.015
rs13418037 2 218,314,141 DIRC3 C T −0.020 0.003 −0.006 0.011 −0.017 0.016 0.003 0.016 −0.002 0.014 0.002 0.018 −0.010 0.018 −0.036 0.018
rs62182127 2 219,279,588 VIL1 A G 0.019 0.003 0.017 0.009 0.005 0.013 0.029 0.013 0.019 0.011 0.012 0.014 0.024 0.014 0.027 0.014
rs11678946 2 222,302,730 EPHA4 C A −0.014 0.003 0.003 0.009 0.003 0.012 0.003 0.013 −0.007 0.011 0.005 0.014 −0.024 0.014 0.012 0.014
rs4402747 2 225,457,173 CUL3 G A −0.016 0.003 0.003 0.009 0.002 0.012 0.002 0.013 −0.004 0.011 −0.006 0.014 0.007 0.014 0.013 0.014
rs17323117 2 230,162,971 PID1 A G −0.029 0.005 −0.014 0.017 −0.022 0.024 0.000 0.025 −0.029 0.020 −0.064 0.026 0.001 0.027 0.035 0.027
rs1465529 2 231,039,037 SP110 T C 0.019 0.003 0.009 0.010 −0.003 0.014 0.018 0.014 0.017 0.012 0.017 0.015 0.020 0.015 0.007 0.015
rs6437249 2 242,175,331 HDLBP C T 0.019 0.003 −0.018 0.010 −0.014 0.014 −0.021 0.014 −0.010 0.012 −0.008 0.015 −0.016 0.015 −0.030 0.015
rs7625680 3 11,378,069 ATG7 A G 0.015 0.003 0.005 0.009 0.004 0.013 0.007 0.013 0.007 0.011 0.012 0.014 −0.004 0.014 −0.002 0.014
rs1822825 3 12,449,963 PPARG A G −0.014 0.003 0.005 0.009 0.014 0.012 −0.005 0.013 0.013 0.011 0.001 0.014 0.026 0.014 0.002 0.014
rs2607748 3 14,158,725 CHCHD4 T C −0.017 0.003 −0.007 0.009 0.002 0.012 −0.017 0.013 −0.005 0.011 0.000 0.014 −0.005 0.014 −0.020 0.014
rs11717397 3 23,368,583 UBE2E2 G A 0.015 0.003 −0.001 0.009 −0.027 0.012 0.027 0.013 −0.008 0.011 −0.017 0.014 −0.002 0.014 0.018 0.014
rs2362755 3 24,716,668 THRB−AS1 G T −0.016 0.003 0.006 0.009 −0.001 0.012 0.012 0.013 0.004 0.011 −0.016 0.014 0.026 0.014 −0.009 0.014
rs11928797 3 33,457,493 UBP1 A C 0.030 0.004 −0.003 0.015 0.003 0.021 −0.005 0.022 −0.017 0.018 −0.023 0.023 0.004 0.024 0.008 0.023
rs33969824 3 42,679,777 NKTR G T 0.020 0.004 0.002 0.013 0.014 0.018 −0.014 0.019 0.030 0.016 0.036 0.021 0.020 0.021 −0.011 0.021
rs12491473 3 46,989,904 CCDC12 G A 0.020 0.003 0.019 0.009 0.025 0.012 0.009 0.013 0.019 0.011 0.024 0.014 0.011 0.014 0.021 0.014
rs2228561 3 48,628,014 COL7A1 A G 0.020 0.004 0.005 0.014 0.007 0.019 0.004 0.020 0.007 0.017 −0.008 0.022 0.017 0.022 −0.003 0.022
rs4768 3 49,758,764 RNF123 A G −0.015 0.003 0.008 0.010 0.005 0.013 0.007 0.014 0.010 0.012 0.021 0.015 0.000 0.015 −0.006 0.015
rs9809209 3 51,281,664 DOCK3 G A −0.017 0.003 0.007 0.009 0.009 0.013 0.005 0.013 0.014 0.011 0.007 0.014 0.030 0.015 −0.026 0.014
rs112893170 3 57,211,863 IL17RD T C 0.020 0.003 0.012 0.012 0.013 0.017 0.012 0.017 0.019 0.014 −0.003 0.019 0.043 0.019 0.008 0.019
rs7628689 3 88,216,647 C3orf38 G A 0.029 0.003 0.014 0.013 0.016 0.017 0.010 0.018 0.009 0.015 0.000 0.020 0.026 0.020 0.023 0.020
rs3772102 3 98,502,628 ST3GAL6 T G −0.020 0.003 0.006 0.009 0.007 0.013 0.004 0.013 0.008 0.011 0.004 0.014 0.023 0.014 0.018 0.014
rs62280667 3 101,084,604 SENP7 T C −0.028 0.003 −0.006 0.009 −0.005 0.013 −0.008 0.013 −0.006 0.011 0.001 0.015 0.000 0.015 0.011 0.015
rs62263345 3 107,252,190 BBX A G 0.028 0.004 −0.002 0.014 −0.012 0.019 0.006 0.019 0.008 0.016 0.007 0.021 0.013 0.021 −0.011 0.021
rs13069961 3 124,358,715 KALRN A G −0.018 0.003 0.001 0.011 0.004 0.015 −0.002 0.015 −0.003 0.013 0.002 0.017 −0.008 0.017 0.002 0.017
rs687339 3 135,932,359 AC092991.1 T C 0.040 0.003 0.012 0.010 −0.003 0.015 0.027 0.015 0.014 0.013 −0.001 0.016 0.011 0.017 0.004 0.016
rs811332 3 138,078,348 MRAS C T 0.019 0.003 −0.021 0.011 −0.009 0.016 −0.035 0.016 −0.035 0.013 −0.039 0.017 −0.026 0.018 0.015 0.018
rs55717031 3 138,848,505 MRPS22 G T 0.032 0.003 −0.001 0.010 0.006 0.014 −0.003 0.014 0.012 0.012 0.019 0.015 0.005 0.015 −0.007 0.015
rs6440008 3 141,154,542 ZBTB38 T C 0.035 0.003 −0.007 0.009 −0.015 0.013 −0.002 0.013 −0.017 0.011 −0.026 0.014 −0.004 0.015 0.000 0.014
rs73238159 3 142,078,759 XRN1 T C −0.025 0.004 −0.010 0.013 −0.019 0.018 −0.003 0.019 −0.003 0.016 0.010 0.021 −0.003 0.021 −0.002 0.021
rs13073970 3 170,630,520 EIF5A2 G T −0.025 0.003 0.009 0.011 0.001 0.015 0.017 0.015 0.008 0.013 0.000 0.017 0.013 0.017 0.004 0.017
rs56062334 3 172,299,226 LINC02068 T C 0.017 0.003 −0.007 0.009 −0.017 0.013 0.004 0.013 −0.006 0.011 −0.007 0.015 −0.004 0.015 −0.021 0.015
rs9819762 3 178,914,879 PIK3CA T C 0.019 0.003 −0.030 0.011 −0.023 0.016 −0.038 0.016 −0.040 0.013 −0.053 0.017 −0.011 0.018 −0.031 0.017
rs66707192 3 186,382,065 HRG G A 0.018 0.003 0.012 0.010 0.025 0.014 0.000 0.014 0.007 0.012 0.003 0.016 0.005 0.016 0.001 0.016
rs13108218 4 3,443,931 HGFAC G A 0.017 0.003 0.002 0.009 −0.005 0.013 0.008 0.013 −0.009 0.011 −0.002 0.014 −0.002 0.015 0.011 0.014
rs1055582 4 39,700,173 UBE2K C T 0.027 0.003 −0.021 0.009 −0.016 0.012 −0.027 0.013 −0.027 0.011 −0.027 0.014 −0.020 0.014 −0.010 0.014
rs62302688 4 46,448,465 GABRA2 G A 0.039 0.004 −0.006 0.017 0.022 0.023 −0.033 0.024 0.017 0.020 −0.007 0.026 0.025 0.026 −0.035 0.025
rs115805235 4 69,764,890 AC021146.3 C T 0.039 0.006 −0.032 0.023 −0.080 0.032 0.022 0.033 −0.025 0.027 −0.032 0.035 −0.008 0.036 −0.037 0.035
rs16845929 4 72,017,058 SLC4A4 C T 0.032 0.005 0.003 0.019 0.018 0.027 −0.016 0.028 0.004 0.023 0.027 0.030 −0.019 0.030 0.012 0.030
rs2280099 4 90,035,549 TIGD2 G A 0.025 0.003 −0.006 0.011 −0.011 0.016 −0.004 0.016 0.012 0.014 0.037 0.018 −0.003 0.018 −0.017 0.018
rs35036084 4 97,552,791 LINC02267 T C 0.017 0.003 0.007 0.009 0.009 0.013 0.006 0.013 0.003 0.011 0.002 0.014 −0.004 0.014 0.017 0.014
rs6532798 4 100,054,827 ADH4 T C 0.037 0.003 0.003 0.010 −0.009 0.013 0.018 0.014 0.009 0.011 0.005 0.015 0.005 0.015 0.006 0.015
rs62342064 4 104,665,972 TACR3 C T 0.022 0.004 −0.011 0.014 −0.002 0.020 −0.021 0.021 0.002 0.017 0.017 0.022 −0.017 0.023 −0.009 0.022
rs17429745 4 106,038,169 AC096577.1 G T 0.026 0.003 0.022 0.010 0.043 0.013 −0.002 0.014 0.019 0.011 0.005 0.015 0.032 0.015 0.027 0.015
rs3804173 4 121,719,923 PRDM5 A G −0.020 0.003 −0.004 0.009 0.007 0.013 −0.020 0.013 −0.005 0.011 −0.023 0.015 0.007 0.015 −0.019 0.015
rs111443396 4 124,773,202 LINC01091 T C −0.026 0.004 0.014 0.014 0.020 0.019 0.008 0.020 −0.006 0.016 −0.011 0.021 0.004 0.021 0.048 0.021
rs7667562 4 129,133,826 LARP1B C A 0.016 0.003 0.017 0.010 0.007 0.014 0.032 0.014 0.029 0.012 0.036 0.016 0.020 0.016 0.006 0.016
rs6827641 4 145,653,694 GYPA/HHIP C T −0.014 0.003 −0.020 0.009 −0.032 0.012 −0.008 0.013 −0.023 0.011 −0.007 0.014 −0.037 0.014 −0.017 0.014
rs6853741 4 148,982,559 ARHGAP10 A G 0.024 0.003 −0.004 0.010 −0.014 0.014 0.008 0.015 −0.019 0.012 −0.023 0.016 −0.016 0.016 0.013 0.016
rs62334147 4 169,345,005 DDX60L T C −0.019 0.003 −0.006 0.012 0.003 0.016 −0.012 0.017 0.003 0.014 0.012 0.018 −0.009 0.018 −0.004 0.018
rs4394044 4 186,607,420 SORBS2 T C 0.014 0.003 −0.008 0.009 0.007 0.012 −0.024 0.013 −0.007 0.011 −0.010 0.014 −0.007 0.014 −0.007 0.014
rs9292578 5 35,230,075 PRLR C A 0.040 0.006 0.024 0.022 0.049 0.031 −0.002 0.032 0.022 0.027 −0.016 0.035 0.050 0.036 0.019 0.035
rs6895953 5 39,084,471 RICTOR G A 0.024 0.003 −0.026 0.009 −0.012 0.012 −0.041 0.013 −0.029 0.011 −0.042 0.014 −0.017 0.014 −0.009 0.014
rs72758321 5 41,464,841 PLCXD3 A G −0.047 0.006 0.003 0.025 0.002 0.035 −0.006 0.035 −0.037 0.029 −0.059 0.038 −0.004 0.039 0.037 0.039
rs6180 5 42,719,239 GHR C A −0.035 0.003 −0.005 0.009 −0.001 0.012 −0.007 0.013 −0.005 0.011 -0.019 0.014 0.010 0.014 0.003 0.014
rs12520263 5 44,122,508 RNU6−381P G T −0.017 0.003 0.010 0.010 0.004 0.014 0.015 0.014 0.016 0.012 0.035 0.016 −0.001 0.016 0.018 0.016
rs7719168 5 53,292,390 ARL15 A C −0.030 0.004 −0.024 0.014 −0.038 0.020 −0.008 0.021 −0.025 0.017 −0.023 0.022 −0.027 0.022 −0.023 0.022
rs28650790 5 55,861,464 C5orf67 C T −0.018 0.003 −0.008 0.011 0.016 0.016 −0.032 0.016 −0.019 0.014 −0.031 0.017 −0.009 0.018 0.014 0.018
rs1498603 5 58,333,125 PDE4D T G 0.031 0.005 0.032 0.019 0.055 0.026 0.009 0.026 0.035 0.023 0.056 0.030 0.009 0.030 0.010 0.029
rs11954036 5 59,028,853 PDE4D T C 0.037 0.003 0.006 0.009 −0.001 0.013 0.011 0.013 0.001 0.011 −0.004 0.015 0.011 0.015 −0.001 0.014
rs80170948 5 64,020,316 SREK1IP1 T G −0.039 0.006 0.007 0.025 0.034 0.034 −0.023 0.035 0.018 0.029 0.002 0.038 0.009 0.039 0.011 0.038
rs2227819 5 76,012,745 F2R C T −0.022 0.004 0.022 0.015 0.008 0.021 0.036 0.021 0.020 0.018 0.037 0.023 0.004 0.023 0.039 0.023
rs12108803 5 77,158,507 TBCA T G −0.033 0.006 −0.008 0.022 −0.021 0.031 0.008 0.031 −0.006 0.026 −0.020 0.034 0.009 0.035 −0.011 0.034
rs840809 5 87,173,927 TMEM161B A C 0.016 0.003 −0.022 0.010 −0.003 0.014 −0.044 0.014 −0.034 0.012 −0.029 0.015 −0.040 0.015 −0.002 0.015
rs13178887 5 88,355,993 MEF2C−AS1 T C 0.023 0.003 0.013 0.009 0.002 0.013 0.023 0.013 0.016 0.011 0.015 0.014 0.015 0.014 −0.002 0.014
rs2366398 5 89,437,963 LINC01339 G T −0.018 0.003 0.012 0.011 0.010 0.015 0.015 0.015 0.009 0.013 −0.006 0.016 0.032 0.017 0.013 0.016
rs26822 5 102,518,795 PPIP5K2 A G −0.017 0.003 −0.009 0.010 −0.007 0.013 −0.012 0.014 −0.014 0.012 −0.024 0.015 −0.002 0.015 −0.017 0.015
rs73271090 5 132,313,550 AC010240.1 G A 0.044 0.003 0.010 0.012 0.019 0.017 0.002 0.018 0.003 0.015 −0.008 0.019 0.003 0.020 −0.005 0.019
rs329122 5 133,864,599 JADE2 G A −0.018 0.003 0.003 0.009 0.003 0.012 0.002 0.013 0.006 0.011 0.018 0.014 −0.003 0.014 0.018 0.014
rs11242236 5 134,586,980 C5orf66 G A 0.025 0.003 0.013 0.009 0.021 0.012 0.006 0.013 0.018 0.011 0.025 0.014 0.018 0.014 0.005 0.014
rs2348604 5 136,809,831 SPOCK1 T C −0.016 0.003 −0.004 0.010 −0.008 0.014 −0.001 0.014 −0.011 0.012 −0.005 0.015 −0.020 0.016 0.004 0.015
rs3734166 5 137,665,323 CDC25C A G 0.028 0.003 0.004 0.010 0.014 0.014 −0.005 0.014 0.008 0.012 0.005 0.015 0.011 0.016 −0.008 0.015
rs2042253 5 143,059,433 MIR5197 T C 0.023 0.003 −0.023 0.010 −0.045 0.014 −0.001 0.014 −0.017 0.012 −0.027 0.016 −0.004 0.016 −0.021 0.016
rs35668185 5 168,256,455 SLIT3 T C 0.056 0.003 −0.002 0.011 −0.001 0.015 −0.001 0.015 0.003 0.013 0.012 0.017 −0.009 0.017 −0.008 0.017
rs13168379 5 173,382,761 CPEB4 G A −0.031 0.005 0.003 0.017 −0.003 0.024 0.011 0.024 0.022 0.021 0.024 0.028 0.018 0.028 −0.006 0.027
rs17714046 5 180,661,980 TRIM41 C T 0.042 0.006 0.026 0.024 −0.002 0.033 0.051 0.034 0.032 0.028 0.022 0.037 0.045 0.037 −0.009 0.037
rs584955 6 7,097,141 RREB1 A G 0.036 0.006 0.037 0.021 0.018 0.030 0.053 0.031 0.035 0.026 0.034 0.034 0.039 0.034 0.022 0.034
rs2296198 6 18,399,750 RNF144B C T 0.016 0.003 −0.001 0.010 −0.004 0.014 0.002 0.015 −0.021 0.012 −0.024 0.016 −0.017 0.016 −0.005 0.016
rs72828596 6 19,183,591 AL589647.1 G A −0.019 0.004 −0.012 0.014 −0.019 0.019 −0.006 0.019 −0.040 0.016 −0.038 0.021 −0.059 0.021 0.028 0.021
rs73382439 6 20,404,420 E2F3 C T 0.019 0.003 0.005 0.011 0.000 0.016 0.009 0.016 0.010 0.014 0.015 0.018 0.000 0.018 −0.003 0.018
rs17258904 6 21,928,131 CASC15 A G −0.017 0.003 −0.005 0.010 −0.011 0.014 0.004 0.014 0.002 0.012 −0.007 0.015 0.011 0.016 −0.008 0.015
rs1165196 6 25,813,150 SLC17A1 A G −0.029 0.003 −0.007 0.009 −0.022 0.012 0.010 0.013 0.002 0.011 0.010 0.014 0.005 0.014 −0.014 0.014
rs13195402 6 26,463,575 BTN2A1 T G −0.038 0.004 0.042 0.019 0.026 0.026 0.058 0.027 0.037 0.022 0.066 0.028 0.014 0.029 0.058 0.028
rs16897515 6 27,278,020 POM121L2 A C −0.023 0.003 0.036 0.012 0.022 0.017 0.051 0.017 0.038 0.014 0.051 0.018 0.036 0.019 0.058 0.018
rs33932084 6 28,268,824 PGBD1 G A −0.034 0.004 0.054 0.016 0.041 0.022 0.066 0.023 0.051 0.019 0.096 0.024 0.020 0.025 0.087 0.024
rs9267488 6 31,514,247 ATP6V1G2−DDX39B/ATP6V1G2 G A −0.031 0.004 0.051 0.014 0.059 0.020 0.044 0.020 0.048 0.017 0.057 0.022 0.037 0.022 0.092 0.022
rs1150752 6 32,064,726 TNXB C T −0.031 0.004 0.058 0.015 0.066 0.021 0.047 0.021 0.054 0.018 0.066 0.023 0.041 0.023 0.096 0.022
rs12194618 6 38,091,030 ZFAND3 G A −0.017 0.003 0.007 0.009 0.011 0.013 0.002 0.013 0.009 0.011 −0.003 0.014 0.016 0.015 −0.002 0.014
rs7740433 6 42,908,013 CNPY3 A G 0.017 0.003 0.003 0.011 −0.001 0.015 0.004 0.015 0.018 0.013 0.012 0.016 0.018 0.017 −0.021 0.016
rs998584 6 43,757,896 VEGFA A C 0.020 0.003 0.005 0.009 −0.020 0.012 0.033 0.013 0.009 0.011 0.012 0.014 0.008 0.014 0.007 0.014
rs6924225 6 45,584,732 RUNX2 G A 0.019 0.003 0.005 0.012 0.020 0.017 −0.011 0.017 −0.006 0.014 −0.019 0.019 −0.004 0.019 0.006 0.019
rs2397112 6 52,684,333 GSTA6P A G 0.019 0.003 0.002 0.009 0.008 0.013 −0.004 0.013 −0.003 0.011 −0.001 0.014 0.005 0.014 0.005 0.014
rs9361489 6 79,816,785 PHIP T C 0.022 0.003 0.008 0.009 −0.004 0.012 0.021 0.013 0.018 0.011 0.036 0.014 0.009 0.014 −0.003 0.014
rs6916994 6 87,991,236 GJB7 C T 0.029 0.003 −0.005 0.009 −0.001 0.012 −0.006 0.013 −0.008 0.011 −0.030 0.014 0.015 0.014 0.009 0.014
rs670049 6 100,087,024 PRDM13 A C 0.019 0.003 −0.005 0.009 0.002 0.013 −0.012 0.013 −0.003 0.011 −0.011 0.014 0.001 0.015 −0.004 0.014
rs9322822 6 105,369,598 LIN28B−AS1 C T 0.015 0.003 0.003 0.009 0.016 0.013 −0.011 0.014 0.007 0.011 0.006 0.015 0.006 0.015 0.001 0.015
rs4946810 6 107,420,270 BEND3 A C −0.016 0.003 0.006 0.009 0.004 0.013 0.011 0.013 0.016 0.011 0.012 0.015 0.020 0.015 −0.004 0.014
rs218291 6 108,467,024 OSTM1/OSTM1−AS1 G A 0.016 0.003 0.011 0.009 0.014 0.013 0.007 0.013 0.007 0.011 0.002 0.014 0.009 0.015 0.021 0.014
rs9398171 6 108,983,527 FOXO3 T C 0.050 0.003 0.012 0.010 0.023 0.013 −0.002 0.014 0.022 0.012 0.027 0.015 0.024 0.015 −0.001 0.015
rs41285260 6 126,661,502 CENPW T G 0.039 0.004 -0.007 0.017 -0.012 0.024 -0.005 0.024 -0.012 0.020 0.004 0.026 -0.039 0.027 0.008 0.026
rs9321106 6 128,355,316 PTPRK A G 0.018 0.003 0.016 0.012 0.018 0.017 0.014 0.018 0.004 0.015 0.008 0.019 0.001 0.019 0.030 0.019
rs9398891 6 129,314,749 LAMA2 C T −0.017 0.003 −0.001 0.010 −0.002 0.013 0.001 0.014 0.000 0.011 −0.002 0.015 0.005 0.015 0.007 0.015
rs3890746 6 130,371,055 L3MBTL3 T C −0.020 0.003 0.004 0.009 0.014 0.012 −0.004 0.013 −0.006 0.011 −0.033 0.014 0.020 0.014 0.017 0.014
rs2786185 6 147,595,554 STXBP5 G A 0.019 0.003 0.005 0.009 0.019 0.012 −0.008 0.013 0.004 0.011 −0.009 0.014 0.012 0.014 −0.001 0.014
rs7774230 6 152,164,239 ESR1 C T −0.026 0.003 0.011 0.009 0.007 0.012 0.016 0.013 0.008 0.011 0.013 0.014 0.004 0.014 0.010 0.014
rs790513 6 154,420,368 OPRM1 C A 0.025 0.003 0.006 0.010 −0.015 0.014 0.027 0.015 −0.001 0.012 −0.027 0.016 0.012 0.016 0.011 0.016
rs7758644 6 156,583,467 snoRNA C A −0.019 0.003 0.008 0.012 0.014 0.017 0.000 0.018 0.004 0.015 0.004 0.019 0.008 0.019 0.019 0.019
rs3127579 6 160,674,632 SLC22A2 G A −0.033 0.004 0.012 0.013 0.028 0.019 −0.008 0.019 −0.004 0.016 −0.016 0.021 0.005 0.021 0.028 0.021
rs12211977 6 161,252,770 lincRNA G A −0.023 0.004 0.010 0.016 0.040 0.022 −0.022 0.022 0.024 0.018 0.061 0.024 −0.004 0.024 −0.007 0.024
rs504371 6 165,724,052 C6orf118 C A −0.015 0.003 −0.015 0.009 −0.006 0.013 −0.023 0.013 −0.018 0.011 −0.027 0.014 −0.006 0.015 −0.015 0.014
rs4709995 6 166,313,447 PDE10A C T −0.042 0.003 −0.022 0.009 −0.023 0.013 −0.020 0.013 −0.026 0.011 −0.020 0.014 −0.041 0.014 −0.049 0.014
rs7802508 7 1,191,689 ZFAND2A G A −0.021 0.003 −0.006 0.009 −0.012 0.013 0.001 0.013 −0.007 0.011 −0.012 0.014 −0.001 0.014 −0.023 0.014
rs12699547 7 2,015,970 MAD1L1 C T 0.021 0.003 0.005 0.009 −0.009 0.013 0.022 0.013 0.008 0.011 0.004 0.014 0.010 0.015 0.016 0.014
rs1182174 7 2,875,420 GNA12 G A −0.021 0.003 0.028 0.010 0.029 0.014 0.026 0.014 0.037 0.012 0.036 0.015 0.031 0.015 0.003 0.015
rs2250243 7 6,690,240 ZNF316 T C −0.024 0.003 −0.011 0.010 −0.009 0.014 −0.015 0.015 −0.010 0.012 −0.008 0.016 −0.014 0.016 −0.016 0.016
rs4719393 7 14,219,213 DGKB T G 0.027 0.003 −0.008 0.010 −0.010 0.013 −0.005 0.014 −0.008 0.012 −0.013 0.015 −0.004 0.015 −0.009 0.015
rs10252510 7 31,023,108 GHRHR G A 0.020 0.003 0.001 0.010 −0.009 0.014 0.012 0.015 −0.001 0.012 −0.018 0.016 0.015 0.016 0.007 0.016
rs7790246 7 32,976,416 AVL9/RP9P C T −0.017 0.003 −0.007 0.010 0.000 0.014 −0.013 0.014 0.001 0.012 0.004 0.015 0.005 0.015 0.006 0.015
rs1050327 7 44,808,017 ZMIZ2 G A −0.017 0.003 −0.010 0.009 −0.008 0.012 −0.013 0.013 −0.005 0.011 −0.003 0.014 −0.007 0.014 −0.010 0.014
rs870796 7 45,426,435 ELK1P1 G A 0.017 0.003 −0.007 0.009 −0.006 0.013 −0.010 0.013 −0.004 0.011 0.002 0.014 −0.014 0.014 −0.014 0.014
rs2270628 7 45,949,570 IGFBP3 C T −0.033 0.003 0.023 0.011 0.030 0.015 0.019 0.016 0.024 0.013 0.017 0.017 0.043 0.018 0.048 0.017
rs74657816 7 46,670,682 HMGN1P19 T G 0.047 0.005 0.012 0.019 0.002 0.026 0.021 0.027 −0.004 0.022 0.004 0.029 −0.022 0.029 −0.006 0.029
rs12538762 7 47,264,328 TNS3 C T 0.026 0.004 0.001 0.014 0.002 0.020 −0.003 0.020 −0.004 0.017 −0.002 0.022 −0.006 0.023 −0.012 0.022
rs6974707 7 55,982,894 ZNF713 G A −0.019 0.003 0.009 0.011 0.024 0.015 −0.008 0.015 0.004 0.013 −0.008 0.016 0.023 0.017 0.012 0.017
rs35862187 7 69,625,029 AUTS2 A G 0.031 0.006 0.002 0.020 −0.030 0.028 0.038 0.029 −0.015 0.024 −0.036 0.031 −0.003 0.031 −0.012 0.031
rs17145738 7 72,982,874 TBL2 C T −0.034 0.004 −0.016 0.014 −0.018 0.019 −0.016 0.019 −0.021 0.016 −0.005 0.021 −0.030 0.022 −0.034 0.021
rs411717 7 94,033,031 COL1A2 C T −0.015 0.003 0.009 0.009 0.017 0.012 −0.001 0.013 0.001 0.011 −0.007 0.014 0.010 0.014 0.022 0.014
rs34670419 7 99,130,834 ZKSCAN5 G T −0.036 0.006 0.001 0.024 −0.020 0.033 0.022 0.034 −0.024 0.028 −0.028 0.036 −0.020 0.037 0.045 0.037
rs34312198 7 99,674,870 ZNF3 C A −0.024 0.004 −0.020 0.014 −0.021 0.020 −0.020 0.021 −0.026 0.017 −0.020 0.022 −0.021 0.023 −0.010 0.022
rs7783012 7 114,116,881 FOXP2 A G −0.016 0.003 0.010 0.009 0.017 0.012 0.004 0.013 0.011 0.011 0.018 0.014 0.005 0.014 0.015 0.014
rs12666306 7 115,082,406 AC073901.1 G A 0.017 0.003 −0.001 0.009 0.017 0.012 −0.020 0.013 −0.007 0.011 −0.003 0.014 −0.010 0.014 0.017 0.014
rs2896395 7 127,511,705 SND1 C T 0.015 0.003 −0.010 0.010 −0.016 0.014 −0.003 0.014 −0.018 0.012 −0.015 0.015 −0.021 0.015 −0.007 0.015
rs11556924 7 129,663,496 ZC3HC1 T C −0.016 0.003 0.037 0.009 0.032 0.013 0.043 0.013 0.043 0.011 0.030 0.015 0.047 0.015 0.033 0.015
rs207212 7 130,547,217 LINC00513 C T 0.028 0.004 0.058 0.016 0.075 0.022 0.045 0.022 0.068 0.019 0.057 0.024 0.063 0.025 0.049 0.024
rs1986692 7 133,743,393 EXOC4 A G −0.015 0.003 0.004 0.009 −0.003 0.013 0.011 0.013 0.008 0.011 0.012 0.014 0.003 0.014 −0.004 0.014
rs273956 7 137,603,188 CREB3L2 G A −0.021 0.003 0.011 0.009 0.007 0.013 0.016 0.013 0.012 0.011 0.016 0.014 0.023 0.015 0.021 0.014
rs114949263 7 150,498,245 TMEM176B/TMEM176A T C 0.027 0.004 −0.013 0.014 −0.004 0.020 −0.020 0.021 −0.027 0.017 −0.019 0.022 −0.044 0.022 −0.023 0.022
rs10246481 7 156,184,748 lincRNA A G −0.015 0.003 0.004 0.009 0.004 0.013 0.006 0.013 0.006 0.011 0.018 0.014 −0.020 0.014 0.002 0.014
rs9657541 8 10,643,164 SOX7/PINX1/PINX1 C T 0.020 0.003 −0.002 0.011 −0.010 0.016 0.007 0.016 −0.006 0.013 0.004 0.017 −0.015 0.017 −0.002 0.017
rs76393968 8 16,282,937 MSR1 G A 0.060 0.010 0.035 0.034 0.018 0.048 0.060 0.051 0.029 0.044 0.036 0.058 0.025 0.059 0.015 0.057
rs1495741 8 18,272,881 NAT2 A G −0.026 0.003 0.010 0.010 0.010 0.015 0.009 0.015 0.011 0.013 0.012 0.016 0.013 0.017 0.012 0.016
rs11782452 8 26,361,601 BNIP3L G A 0.015 0.003 −0.002 0.009 0.000 0.013 −0.005 0.013 −0.002 0.011 0.009 0.014 −0.009 0.014 −0.001 0.014
rs56352849 8 73,769,173 KCNB2 G A −0.016 0.003 −0.011 0.010 −0.012 0.014 −0.005 0.014 −0.017 0.012 −0.038 0.015 −0.002 0.016 −0.010 0.015
rs1431015 8 77,131,580 HNF4G C T 0.020 0.003 0.008 0.009 0.014 0.012 −0.001 0.013 0.003 0.011 0.008 0.014 −0.001 0.014 0.016 0.014
rs6473015 8 78,178,485 lincRNA A C −0.019 0.003 −0.028 0.010 −0.025 0.014 −0.034 0.014 −0.024 0.012 −0.031 0.015 −0.019 0.015 −0.035 0.015
rs445036 8 81,408,409 ZBTB10 T C 0.019 0.003 −0.007 0.010 −0.008 0.013 −0.007 0.014 0.004 0.011 0.015 0.015 −0.012 0.015 −0.029 0.015
rs1786342 8 101,676,363 SNX31 T C 0.017 0.003 0.022 0.009 0.030 0.013 0.011 0.013 0.023 0.011 0.014 0.014 0.032 0.014 0.016 0.014
rs60862542 8 109,275,071 EIF3E G A 0.017 0.003 −0.005 0.011 −0.018 0.015 0.008 0.015 −0.010 0.013 −0.007 0.016 −0.015 0.017 −0.010 0.016
rs2737205 8 116,610,180 TRPS1 C T −0.023 0.003 −0.013 0.009 −0.005 0.013 −0.021 0.013 −0.028 0.011 −0.023 0.014 −0.034 0.014 0.010 0.014
rs2978062 8 134,571,618 ST3GAL1 T G −0.019 0.003 −0.007 0.013 0.009 0.018 −0.023 0.018 −0.004 0.015 0.018 0.020 −0.035 0.020 0.019 0.020
rs716100 8 135,661,278 ZFAT G A −0.019 0.003 −0.017 0.009 −0.018 0.013 −0.013 0.013 0.002 0.011 −0.001 0.015 0.005 0.015 −0.039 0.015
rs12549853 8 145,020,636 PLEC G A −0.016 0.003 0.011 0.009 0.009 0.013 0.015 0.013 0.006 0.011 0.014 0.014 −0.004 0.014 0.009 0.014
rs10114121 9 19,440,136 ACER2 G A −0.020 0.004 −0.021 0.012 −0.025 0.017 −0.018 0.018 −0.019 0.015 −0.013 0.019 −0.023 0.019 −0.019 0.019
rs10757291 9 22,161,884 CDKN2B−AS1 A G −0.019 0.003 0.007 0.009 0.010 0.012 0.006 0.013 0.008 0.011 0.018 0.014 −0.008 0.014 0.011 0.014
rs10811787 9 22,871,816 AL391117.1 T C −0.015 0.003 −0.009 0.009 −0.011 0.012 −0.009 0.013 −0.010 0.011 −0.020 0.014 −0.008 0.014 −0.002 0.014
rs11557154 9 34,107,505 DCAF12 T C 0.024 0.004 0.036 0.013 0.038 0.018 0.029 0.018 0.045 0.016 0.051 0.020 0.041 0.021 0.050 0.020
rs10869022 9 74,057,313 TRPM3 C T 0.021 0.003 0.005 0.011 0.027 0.015 −0.016 0.015 0.020 0.013 0.019 0.017 0.024 0.017 −0.020 0.017
rs2378662 9 86,707,289 AL390838.1 A G −0.017 0.003 0.004 0.009 −0.007 0.012 0.019 0.013 0.008 0.011 0.020 0.014 −0.003 0.014 0.018 0.014
rs10908903 9 92,228,559 GADD45G T G 0.015 0.003 0.015 0.009 0.012 0.012 0.019 0.013 0.013 0.011 0.019 0.014 0.007 0.014 0.014 0.014
rs1055710 9 96,214,928 FAM120AOS A G −0.018 0.003 −0.013 0.009 −0.014 0.013 −0.011 0.013 −0.011 0.011 −0.039 0.015 0.017 0.015 0.000 0.015
rs75660441 9 97,662,448 C9orf3 A G 0.039 0.005 −0.029 0.018 −0.024 0.026 −0.030 0.026 −0.032 0.022 −0.049 0.028 −0.016 0.029 −0.038 0.028
rs28831479 9 98,254,526 PTCH1 C A 0.022 0.003 0.001 0.010 0.007 0.014 −0.002 0.014 0.002 0.012 −0.016 0.016 0.015 0.016 0.001 0.016
rs7034716 9 101,858,382 TGFBR1 C T 0.015 0.003 0.013 0.010 −0.030 0.014 0.006 0.014 −0.008 0.012 0.004 0.016 −0.024 0.016 −0.016 0.016
rs6479003 9 102,948,685 INVS G A 0.024 0.004 0.022 0.016 0.035 0.022 0.006 0.023 0.029 0.019 0.025 0.025 0.015 0.025 0.021 0.024
rs41277821 9 109,689,972 ZNF462 T C 0.062 0.009 0.005 0.038 0.013 0.054 −0.005 0.055 −0.018 0.046 −0.007 0.060 −0.021 0.062 0.021 0.058
rs7872812 9 119,341,544 ASTN2 C T −0.026 0.004 −0.007 0.013 −0.023 0.017 0.004 0.018 −0.003 0.015 0.019 0.019 −0.027 0.019 −0.017 0.019
rs13301073 9 128,284,378 MAPKAP1 G A 0.022 0.003 0.005 0.009 0.000 0.013 0.012 0.013 0.008 0.011 0.017 0.014 −0.005 0.015 −0.005 0.014
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rs12927172 16 27,325,021 IL4R G A −0.015 0.003 0.006 0.009 0.021 0.013 −0.013 0.013 0.015 0.011 0.002 0.014 0.033 0.015 0.012 0.014
rs7498665 16 28,883,241 SH2B1 G A 0.019 0.003 0.006 0.009 0.009 0.013 0.003 0.013 0.008 0.011 0.015 0.014 0.013 0.014 0.008 0.014
rs4788220 16 30,063,780 FAM57B A G −0.017 0.003 −0.003 0.009 −0.002 0.012 −0.003 0.013 −0.006 0.011 0.000 0.014 −0.008 0.014 0.004 0.014
rs750952 16 31,093,954 ZNF646 C T 0.032 0.003 −0.014 0.009 −0.012 0.013 −0.015 0.013 −0.015 0.011 −0.034 0.014 0.000 0.014 −0.008 0.014
rs116971887 16 51,170,026 SALL1 G T 0.036 0.006 −0.018 0.022 0.023 0.030 −0.047 0.031 −0.025 0.026 −0.034 0.033 −0.007 0.034 −0.009 0.034
rs12597502 16 53,170,069 CHD9 A G −0.015 0.003 −0.001 0.010 −0.002 0.014 −0.001 0.014 0.005 0.012 0.004 0.015 0.006 0.015 −0.018 0.015
rs1548917 16 56,109,333 CES5A C T −0.015 0.003 −0.010 0.009 −0.010 0.012 −0.010 0.013 −0.009 0.011 −0.021 0.014 0.003 0.014 −0.002 0.014
rs111792934 16 69,131,293 HAS3 C T 0.022 0.003 0.018 0.012 0.001 0.017 0.039 0.017 0.023 0.015 0.042 0.019 0.018 0.019 0.005 0.019
rs17299478 16 69,775,500 − C T 0.032 0.003 −0.008 0.012 −0.009 0.017 −0.009 0.018 −0.021 0.015 −0.018 0.019 −0.014 0.020 0.003 0.019
rs12935091 16 71,525,208 ZNF19 A G −0.035 0.006 −0.022 0.023 −0.080 0.032 0.032 0.032 −0.022 0.027 0.001 0.036 −0.053 0.036 −0.061 0.035
rs147491123 16 72,567,795 LINC01572 C T 0.036 0.007 0.026 0.024 0.025 0.034 0.030 0.035 0.025 0.029 0.004 0.037 0.060 0.039 0.062 0.038
rs8059803 16 81,603,001 CMIP A G 0.031 0.003 0.005 0.010 −0.010 0.014 0.019 0.014 0.001 0.012 −0.005 0.015 0.003 0.015 −0.008 0.015
rs11149612 16 83,980,965 AC009119.2 C T 0.027 0.003 0.010 0.009 −0.001 0.013 0.022 0.014 0.002 0.011 0.003 0.015 0.005 0.015 0.015 0.015
rs8054322 16 85,201,405 GSE1 G A −0.015 0.003 −0.009 0.009 −0.009 0.013 −0.009 0.013 0.000 0.011 0.004 0.014 −0.002 0.014 −0.014 0.014
rs7502910 17 1,638,718 WDR81 A G 0.016 0.003 0.009 0.009 0.009 0.012 0.011 0.013 0.016 0.011 0.006 0.014 0.031 0.014 0.008 0.014
rs2309401 17 5,471,902 NLRP1 T G 0.015 0.003 0.006 0.009 0.019 0.013 −0.009 0.013 −0.001 0.011 −0.006 0.014 0.007 0.014 0.030 0.014
rs9892862 17 7,439,014 POLR2A G A 0.022 0.003 −0.002 0.010 −0.002 0.015 −0.006 0.015 0.008 0.013 0.007 0.017 0.014 0.017 −0.017 0.016
rs6416868 17 15,924,370 TTC19 G A −0.019 0.003 −0.010 0.009 −0.025 0.012 0.006 0.013 −0.007 0.011 −0.002 0.014 −0.013 0.014 −0.010 0.014
rs8075153 17 17,622,666 RAI1 C T 0.021 0.003 −0.020 0.009 −0.021 0.012 −0.017 0.013 −0.022 0.011 −0.034 0.014 −0.006 0.014 −0.004 0.014
rs8079923 17 19,869,544 AKAP10 C T 0.016 0.003 0.004 0.010 0.000 0.014 0.010 0.015 −0.007 0.012 −0.028 0.016 0.004 0.016 0.021 0.016
rs56030650 17 38,131,187 GSDMA A C −0.022 0.003 0.005 0.009 −0.007 0.012 0.022 0.013 0.004 0.011 −0.010 0.014 0.013 0.014 0.023 0.014
rs668799 17 40,716,235 COASY C T 0.018 0.003 −0.022 0.010 −0.038 0.014 −0.004 0.014 −0.032 0.012 −0.022 0.016 −0.036 0.016 −0.027 0.016
rs199525 17 44,847,834 WNT3 T G −0.020 0.003 0.014 0.011 −0.006 0.015 0.034 0.016 0.011 0.013 0.006 0.017 0.016 0.017 −0.002 0.017
rs11079157 17 53,360,799 HLF G T −0.020 0.003 0.003 0.011 −0.011 0.015 0.021 0.016 0.019 0.013 −0.001 0.017 0.039 0.018 −0.025 0.017
rs2250014 17 57,836,134 VMP1 T C −0.021 0.003 −0.029 0.012 −0.030 0.017 −0.022 0.017 −0.038 0.014 −0.056 0.018 −0.011 0.019 0.001 0.019
rs142377191 17 61,649,170 DCAF7 G A −0.125 0.009 0.028 0.036 0.012 0.050 0.049 0.052 0.059 0.043 0.110 0.057 0.004 0.056 −0.025 0.055
rs76708468 17 62,206,299 ERN1 T C −0.087 0.006 0.009 0.030 −0.013 0.042 0.028 0.043 0.023 0.036 0.002 0.047 0.013 0.048 −0.033 0.046
rs78357146 17 64,305,051 PRKCA A G −0.090 0.007 0.048 0.028 0.018 0.039 0.083 0.041 0.027 0.033 −0.002 0.043 0.072 0.044 0.100 0.044
rs77542162 17 67,081,278 ABCA6 G A 0.054 0.009 0.031 0.037 0.055 0.052 −0.008 0.054 0.025 0.044 0.024 0.057 0.055 0.058 0.049 0.057
rs6501601 17 71,124,903 SLC39A11 G A 0.015 0.003 −0.009 0.010 −0.025 0.013 0.006 0.014 −0.020 0.011 −0.029 0.015 −0.007 0.015 −0.007 0.015
rs4789227 17 73,794,354 UNK T C 0.015 0.003 0.004 0.009 0.018 0.013 −0.012 0.013 0.002 0.011 0.001 0.014 0.011 0.015 0.012 0.014
rs4075483 17 79,074,817 BAIAP2 C T 0.017 0.003 0.000 0.009 −0.015 0.013 0.015 0.013 0.008 0.011 0.001 0.014 0.018 0.015 −0.033 0.014
rs8095538 18 1,616,505 − T G −0.020 0.003 0.003 0.010 0.011 0.013 −0.005 0.014 −0.004 0.011 −0.012 0.015 −0.005 0.015 0.009 0.015
rs8084351 18 50,726,559 DCC G A 0.015 0.003 −0.011 0.009 −0.008 0.012 −0.013 0.013 −0.014 0.011 −0.014 0.014 −0.022 0.014 −0.001 0.014
rs11152071 18 56,087,417 AC105105.3 C T 0.020 0.003 0.007 0.010 −0.003 0.014 0.016 0.015 0.007 0.012 −0.007 0.016 0.020 0.016 0.012 0.016
rs190102446 18 57,048,571 − C T 0.041 0.007 −0.007 0.023 −0.018 0.032 0.011 0.034 −0.013 0.028 0.010 0.036 −0.044 0.036 0.002 0.036
rs585187 18 58,177,124 MRPS5P4 T G 0.015 0.003 −0.008 0.009 −0.010 0.012 −0.005 0.013 −0.013 0.011 −0.026 0.014 0.001 0.014 −0.006 0.014
rs12454712 18 60,845,884 BCL2 T C 0.018 0.003 0.003 0.009 −0.005 0.013 0.012 0.013 0.007 0.011 0.003 0.015 0.012 0.015 −0.003 0.015
rs8097893 18 74,983,055 GALR1 A G 0.058 0.006 −0.009 0.021 0.018 0.030 −0.034 0.031 −0.007 0.026 0.023 0.034 −0.020 0.034 0.041 0.034
rs67868323 19 4,048,561 ZBTB7A T G 0.016 0.003 −0.006 0.010 0.016 0.014 −0.028 0.014 0.007 0.012 0.032 0.016 −0.031 0.016 −0.033 0.015
rs2602717 19 4,902,950 UHRF1/ARRDC5 C T 0.019 0.003 0.024 0.011 0.034 0.016 0.017 0.017 0.030 0.014 0.019 0.018 0.033 0.018 0.033 0.018
rs8112883 19 7,179,320 INSR G T 0.017 0.003 0.007 0.010 0.011 0.014 0.005 0.014 0.006 0.012 0.004 0.015 0.014 0.015 0.028 0.015
rs8105174 19 10,347,032 DNMT1 C T 0.050 0.003 0.010 0.012 0.018 0.016 0.004 0.017 0.021 0.014 0.014 0.018 0.030 0.018 −0.003 0.018
rs6510033 19 30,710,785 AC005597.1 A G 0.020 0.003 0.007 0.010 0.001 0.014 0.015 0.014 0.012 0.012 0.000 0.015 0.022 0.016 0.002 0.015
rs6510177 19 31,211,647 ZNF536 C T −0.023 0.003 0.032 0.013 0.024 0.017 0.042 0.018 0.035 0.015 0.021 0.019 0.063 0.020 0.040 0.020
rs62102136 19 34,700,561 LSM14A C T 0.016 0.003 −0.007 0.010 0.008 0.014 −0.022 0.014 −0.014 0.012 −0.010 0.015 −0.011 0.015 −0.002 0.015
rs7254601 19 36,147,315 COX6B1 A G −0.016 0.003 0.017 0.010 0.027 0.014 0.005 0.015 0.014 0.012 0.005 0.016 0.022 0.016 −0.013 0.016
rs58560372 19 38,758,752 SPINT2 C T 0.020 0.003 0.011 0.013 0.023 0.018 −0.004 0.018 −0.012 0.015 −0.016 0.020 −0.023 0.020 0.016 0.020
rs15052 19 41,813,375 HNRNPUL1/TGFB1 T C −0.018 0.003 −0.014 0.013 −0.037 0.018 0.010 0.018 −0.001 0.015 −0.011 0.020 0.015 0.020 −0.039 0.020
rs11671304 19 47,564,643 ZC3H4 T C −0.018 0.003 0.007 0.010 −0.006 0.014 0.022 0.014 0.003 0.012 0.013 0.015 −0.012 0.015 0.009 0.015
rs296361 19 48,389,363 SULT2A1 G A −0.025 0.003 0.008 0.012 0.018 0.017 −0.005 0.017 0.016 0.014 −0.001 0.019 0.021 0.019 0.004 0.019
rs2287922 19 49,232,226 RASIP1 A G −0.030 0.003 0.022 0.009 0.020 0.013 0.025 0.013 0.034 0.011 0.044 0.014 0.023 0.014 −0.006 0.014
rs7256521 19 53,837,110 ZNF845 A G −0.015 0.003 −0.002 0.009 −0.005 0.013 0.001 0.013 −0.006 0.011 0.008 0.014 −0.013 0.015 −0.003 0.014
rs12975366 19 54,759,361 LILRB5 C T −0.020 0.003 −0.002 0.009 0.014 0.013 −0.021 0.013 −0.005 0.011 −0.002 0.014 −0.018 0.015 0.006 0.014
rs6037508 20 3,217,989 SLC4A11 T G −0.017 0.003 −0.020 0.011 −0.019 0.015 −0.022 0.016 −0.029 0.013 −0.045 0.017 −0.020 0.017 0.001 0.017
rs7267595 20 10,643,850 JAG1 A C 0.015 0.003 0.005 0.009 0.023 0.012 −0.012 0.013 −0.004 0.011 −0.015 0.014 0.006 0.014 0.012 0.014
rs2273058 20 20,033,319 CRNKL1 G A −0.022 0.003 −0.005 0.009 −0.002 0.012 −0.008 0.013 −0.011 0.011 −0.013 0.014 −0.009 0.014 −0.002 0.014
rs6106324 20 20,964,988 AL133465.1 T C 0.019 0.003 −0.011 0.009 −0.009 0.013 −0.012 0.013 −0.008 0.011 −0.011 0.014 −0.007 0.014 −0.010 0.014
rs2424396 20 21,630,280 LINC01726 A G −0.033 0.004 0.016 0.016 0.003 0.022 0.026 0.022 0.025 0.019 0.034 0.024 0.022 0.025 0.020 0.024
rs6088579 20 33,284,624 PIGU/NCOA6 G A 0.027 0.003 −0.016 0.012 −0.021 0.017 −0.011 0.017 −0.010 0.014 −0.016 0.019 −0.004 0.019 −0.045 0.019
rs2207132 20 39,142,516 MAFB G A 0.048 0.007 0.059 0.028 0.033 0.039 0.090 0.042 0.033 0.034 0.046 0.045 0.000 0.045 0.059 0.045
rs17265513 20 39,832,628 ZHX3 C T −0.022 0.003 −0.016 0.011 −0.029 0.016 −0.001 0.016 −0.018 0.014 −0.014 0.017 −0.017 0.018 −0.005 0.017
rs16995311 20 49,201,102 PTPN1 A C 0.040 0.005 0.024 0.018 0.036 0.024 0.010 0.025 0.015 0.021 0.006 0.027 0.027 0.028 0.032 0.027
rs2104476 20 54,852,856 − A G −0.020 0.003 0.006 0.010 0.012 0.014 −0.001 0.014 0.003 0.012 0.006 0.015 0.003 0.016 −0.004 0.015
rs2738787 20 62,328,375 RTEL1−TNFRSF6B/RTEL1 G A −0.037 0.005 −0.028 0.017 −0.060 0.023 0.007 0.024 −0.005 0.020 0.001 0.026 0.000 0.026 −0.064 0.025
rs9978775 21 40,694,526 BRWD1−AS1 G A 0.019 0.003 0.009 0.009 0.021 0.012 −0.001 0.013 0.008 0.011 0.008 0.014 0.001 0.014 0.011 0.014
rs8138950 22 29,448,643 ZNRF3 C T 0.015 0.003 0.016 0.009 0.013 0.012 0.020 0.013 0.005 0.011 −0.004 0.014 0.010 0.014 0.032 0.014
rs2412973 22 30,529,631 HORMAD2 C A −0.014 0.003 0.024 0.009 0.011 0.012 0.035 0.013 0.028 0.011 0.037 0.014 0.022 0.014 0.016 0.014
rs12106594 22 31,885,316 DRG1/EIF4ENIF1/SFI1 C T −0.036 0.006 0.007 0.020 −0.017 0.028 0.030 0.029 0.008 0.024 0.010 0.031 −0.004 0.031 0.003 0.031
rs5755948 22 36,179,095 RBFOX2 G A −0.028 0.004 0.003 0.013 0.008 0.018 −0.005 0.019 0.011 0.016 0.028 0.020 −0.005 0.021 −0.001 0.020
rs6519133 22 39,096,602 JOSD1 T C 0.029 0.003 0.011 0.009 0.012 0.013 0.011 0.013 0.005 0.011 0.013 0.014 0.002 0.015 0.024 0.014
rs9611565 22 41,767,486 TEF T C 0.029 0.003 0.001 0.010 0.010 0.014 −0.010 0.015 0.006 0.012 −0.001 0.016 0.006 0.016 −0.015 0.016
rs4823324 22 46,238,123 ATXN10 T C 0.016 0.003 0.002 0.009 0.001 0.013 0.003 0.013 0.006 0.011 0.023 0.014 −0.013 0.014 0.000 0.014
IGFBP3 - n SNPs = 4
rs4234798 4 7,219,933 SORCS2 G T 0.095 0.011 0.012 0.009 0.020 0.013 0.003 0.013 0.005 0.011 −0.003 0.014 0.015 0.014 0.015 0.014
rs11977526 7 46,008,110 IGFBP3 A G 0.287 0.011 0.037 0.009 0.034 0.013 0.042 0.013 0.042 0.011 0.042 0.014 0.042 0.014 0.037 0.014
rs700753 7 46,753,684 TNS3 G C 0.158 0.011 −0.006 0.009 −0.006 0.013 −0.007 0.013 −0.009 0.011 0.001 0.014 −0.025 0.015 −0.010 0.014
rs1065656 16 1,838,836 NUBP2 G C 0.111 0.011 0.010 0.010 0.015 0.013 0.006 0.014 −0.003 0.012 0.004 0.015 −0.010 0.015 0.017 0.015

Chr, chromosome; SE, standard error.

a

Overlapped or nearest gene (sourced from: https://snp-nexus.org/index.html). Where blank, gene unknown.