Supplementary Table 3.
Risk (HRs) of Colorectal Cancer Associated With Circulating IGF1 Levels With Those Participants With Circulating HbA1c Levels ≥48 mmol/mol (or 6.5%, the Cutoff for Type 2 Diabetes) Excluded
| Q1 | Q2 | Q3 | Q4 | Q5 | P-trend | HR per 1-SD increment | HR per 1-SD increment (adjusted)a | |
|---|---|---|---|---|---|---|---|---|
| Colorectal cancer | ||||||||
| Both sexes | 1 | 1.13 (1.00–1.27) | 1.14 (1.01–1.29) | 1.12 (0.98–1.27) | 1.34 (1.18–1.53) | <0.0001 | 1.09 (1.04–1.14) | 1.12 (1.06–1.18) |
| Colon cancer | ||||||||
| Both sexes | 1 | 1.06 (0.91–1.22) | 1.09 (0.94–1.26) | 1.06 (0.91–1.24) | 1.34 (1.15–1.57) | 0.002 | 1.08 (1.03–1.14) | 1.11 (1.04–1.19) |
| Proximal colon cancer | ||||||||
| Both sexes | 1 | 1.15 (0.94–1.40) | 1.22 (1.00–1.50) | 0.97 (0.77–1.21) | 1.35 (1.08–1.68) | 0.09 | 1.08 (1.00–1.16) | 1.10 (1.00–1.21) |
| Distal colon cancer | ||||||||
| Both sexes | 1 | 0.96 (0.77–1.20) | 0.97 (0.77–1.23) | 1.18 (0.94–1.48) | 1.31 (1.03–1.65) | 0.01 | 1.09 (1.00–1.18) | 1.12 (1.01–1.24) |
| Rectal cancer | ||||||||
| Both sexes | 1 | 1.29 (1.05–1.59) | 1.27 (1.02–1.57) | 1.25 (1.00–1.56) | 1.36 (1.08–1.72) | 0.02 | 1.10 (1.02–1.19) | 1.14 (1.03–1.25) |
NOTE. Multivariable Cox regression model using age as the underlying time variable and stratified by sex, Townsend deprivation index (quintiles), region of the recruitment assessment center, and age at recruitment. Models adjusted for waist circumference (per 5 cm), total physical activity (<10, 10 to <20, 20 to <40, 40 to <60, ≥60 metabolic equivalent hours per week, unknown), height (per 10 cm), alcohol consumption frequency (never, special occasions only, 1–3 times per month, 1–2 times per week, 3–4 times per week, daily/almost daily, unknown), smoking status and intensity (never, former, current- <15 per day, current- ≥15 per day, current- intensity unknown, unknown), frequency of red and processed meat consumption (<2, 2 to <3, 3 to <4, ≥4 occasions per week, unknown), family history of colorectal cancer (no, yes, unknown), educational level (Certificates of secondary education [CSEs]/Ordinary [O]-levels/General Certificates of Secondary Education [GCSEs] or equivalent, National Vocational Qualification [NVQ]/Higher National Diploma [HND]/Higher National Certificate [HNC]/Advanced [A]-levels/Advanced Subsidiary [AS]-levels or equivalent, other professional qualifications, college/university degree, none of the above, unknown), regular aspirin/ibuprofen use (no, yes, unknown), ever use of hormone replacement therapy (no, yes, unknown), and circulating levels (sex-specific quintiles, missing/unknown) of CRP (mg/L), HbA1c (mmol/mol), testosterone (nmol/L), and SHBG (nmol/L).
HRs per SD increment were additionally corrected for regression dilution using a regression dilution ratio (0.76) obtained from the subsample of participants with repeat IGF1 measurements.