Supplementary Table 4.

MR Pleiotropy Sensitivity Tests for the Circulating IGF1 and IGFBP3 Levels and Risk of Colorectal Cancer

	n SNPs	Group	Weighted median approach				MR-Egger test								MR-PRESSO
			OR	LCI	UCI	P	Intercept	LCI	UCI	P	OR	LCI	UCI	P	P Horizontal pleiotropy	P distortion	Outlier SNPs
IGF1	413	Colorectal cancer, both sexes	1.12	1.04	1.20	2.9E−03	−7.1E−04	−3.0E−03	1.6E−03	0.54	1.11	0.98	1.27	0.11	<1e−04	.91	rs1150752 rs174554
		Colorectal cancer, men	1.07	0.97	1.18	0.15	−1.4E−03	−4.5E−03	1.8E−03	0.4	1.18	1.00	1.38	0.05	<1e−04	−	−
		Colorectal cancer, women	1.07	0.97	1.18	0.2	−1.9E−05	−3.3E−03	3.3E−03	0.99	1.06	0.89	1.25	0.53	<1e−04	.82	rs174554
		Colon cancer, both sexes	1.12	1.03	1.23	0.01	−1.7E−03	−4.5E−03	9.9E−04	0.21	1.14	0.98	1.32	0.09	<1e−04	.83	rs174554
		Proximal colon cancer, both sexes	1.08	0.97	1.21	0.16	5.8E−04	−3.0E−03	4.1E−03	0.75	1.02	0.84	1.23	0.84	<1e−04	.90	rs33932084
		Distal colon cancer, both sexes	1.10	0.98	1.23	0.11	−4.2E−03	−7.8E−03	−5.5E−04	0.02	1.26	1.05	1.50	0.01	<1e−04	.82	rs174554
		Rectal cancer, both sexes	1.01	0.90	1.13	0.88	−4.2E−04	−4.0E−03	3.1E−03	0.82	1.09	0.91	1.30	0.36	<1e−04	.85	rs1150752 rs61867536 rs9267488
IGFBP3	4	Colorectal cancer, both sexes	1.14	1.07	1.20	1.1E−05	−0.01	−0.05	0.03	0.35	1.18	1.07	1.31	0.08	.29	−	−
		Colorectal cancer, men	1.13	1.04	1.22	2.8E−03	0.00	−0.06	0.05	0.82	1.14	0.98	1.34	0.23	.72	−	−
		Colorectal cancer, women	1.13	1.04	1.22	3.9E−03	−0.02	−0.08	0.04	0.26	1.25	1.18	1.32	0.02	.18	−	−
		Colon cancer, both sexes	1.13	1.05	1.21	7.9E−04	−0.03	−0.07	0.02	0.16	1.27	1.16	1.38	0.03	.04	−	−
		Proximal colon cancer, both sexes	1.12	1.02	1.23	0.01	−0.02	−0.08	0.04	0.28	1.25	1.21	1.29	0.01	.21	−	−
		Distal colon cancer, both sexes	1.13	1.03	1.24	0.01	−0.03	−0.10	0.03	0.17	1.29	1.01	1.65	0.18	.03	−	−
		Rectal cancer, both sexes	1.14	1.05	1.25	2.6E−03	−0.01	−0.07	0.05	0.57	1.18	1.01	1.39	0.18	.62	−	−

LCI, lower confidence interval; UCI, upper confidence interval.