Table 3.
POT-CAST trial – validation cohort characteristics.
| Total n = 1435 | |
|---|---|
| Trauma, n (%) | |
| High-risk trauma | 100 (7.0) |
| Intermediate-risk trauma | 127 (8.8) |
| Low-risk trauma | 1208 (84.2) |
| Immobilization | |
| Duration of lower-leg cast in weeks, mean (SD) | 4.9 (2.5) |
| Lower-leg cast indication, n (%) | |
| Fracture | 1279 (89.1) |
| Achilles tendon rupture | 94 (6.6) |
| Ankle distortion | 35 (2.5) |
| Antalgic | 9 (0.6) |
| Contusion | 13 (0.9) |
| Other | 5 (0.3) |
| Fracture type, n (%) | |
| Ankle | 497 (34.6) |
| Metatarsal | 532 (37.1) |
| Calcaneus | 56 (3.9) |
| Pilon tibial | 3 (0.2) |
| Tibia and fibula shaft | 3 (0.2) |
| Talus | 50 (3.5) |
| Tarsal | 98 (6.8) |
| Phalanx | 23 (1.6) |
| Lisfranc | 6 (0.4) |
| Othera | 11 (0.8) |
| Surgery, n (%)b | 170 (11.8) |
| Patient characteristicsc | |
| Mean age (SD), years | 46.0 (16.5) |
| Male sex, n (%) | 719 (49.9) |
| Mean BMI (SD), kg/m2 | 25.8 (4.5) |
| Smoking, n (%) | |
| Current | 173 (26.1) |
| Ever | 188 (28.4) |
| Family history of venous thromboembolism (1st degree), n (%) | 140.5 (9.8) |
| Personal history of VTE or known major thrombophilia | Not included |
| Current use of oral contraceptives or Estrogenic hormone therapy | 137 (9.5) |
| Cancer within the past 5 years or active cancer | 36 (2.5) |
| Pregnancy or puerperium | Not included |
| Immobilization (other) | 134.5 (9.4) |
| Surgery within the past 3-months | 232.6 (16.2) |
| Comorbidity | 122.9 (8.6) |
| Varicose veins | 222.2 (15.4) |
SD: standard deviation, BMI: Body Mass Index.
a
Fractures not meeting criteria to be classified in either type.
b
Surgery as part of lower-leg injury treatment.
c
As some patient data were imputed, the total n displays decimals due to imputation,% from known data. Data were missing for the following characteristics: BMI in 100 patients, Smoking in 107 patients, Oral contraceptives use in 45 patients, Cancer in 87 patients, Family history of venous thromboembolism 162 patients.