Table 2.
The laboratory findings of all patients
| Normal range | Media (IQR) |
P value |
|||
|---|---|---|---|---|---|
| Total (N = 204) | non-severe (n = 135) | severe (n = 69) | |||
| White blood cell count, ×109 /L | 3.5-9.5 | 4.75 (3.98-5.94) | 4.74 (4.04-5.76) | 4.84 (3.83-7.85) | 0.021 |
| Neutrophil count, ×109 /L | 1.8-6.3 | 2.93 (2.14-4.05) | 2.69 (2.03-3.61) | 3.87 (2.49-6.11) | ＜0.001 |
| Lymphocyte count, ×109 /L | 1.1-3.2 | 1.17 (0.84-1.61) | 1.43 (1.12-1.88) | 0.76 (0.55-0.93) | ＜0.001 |
| Platelet count, ×109 /L | 125-350 | 189 (153-240) | 200 (167-261) | 171 (138-217) | ＜0.001 |
| Prothrombin time, s | 9-13 | 11.7 (11.1-12.4) | 11.6 (11.0-12.3) | 11.8 (11.2-12.7) | 0.081 |
| D-dimer, mg/L | 0-0.55 | 0.53 (0.23-1.24) | 0.32 (0.20-0.70) | 0.95 (0.41-3.10) | 0.018 |
| Alanine aminotransferase, U/L | 9-50 | 18.5 (14.0-30.0) | 16.5 (11.3-26.5) | 22.5 (16.8-33.3) | 0.137 |
| Aspartate aminotransferase, U/L | 15-40 | 24.0 (19.0-32.0) | 21.0 (17.0-28.8) | 29.0 (22.8-37.0) | 0.002 |
| Urea, mmol/L | 3.1-8.0 | 4.09 (3.21-5.26) | 3.83 (3.02-4.60) | 5.40 (3.95-7.33) | ＜0.001 |
| Creatinine, μmol/L | 57-97 | 60 (48-69) | 54 (47-63) | 89 (51-86) | 0.109 |
| Lactate dehydrogenase, U/L | 120-250 | 211 (169-271) | 188 (161-228) | 276 (214-365) | ＜0.001 |
| Creatine kinase, U/L | 50-310 | 60 (39-101) | 54 (38-86) | 89 (43-129) | 0.152 |
| C-reactive protein, mg/L | 0-5 | 7.4 (0.5-35.0) | 3.45 (0.5-17.1) | 42.7 (11.5-72.5) | ＜0.001 |
| Procalcitonin, ng/mL | <0.1 | 0.05 (0.02-0.13) | 0.023 (0.02-0.05) | 0.102 (0.04-0.28) | 0.017 |
| Hypersensitive troponin I, ng/mL (86)a | 0-0.04 | 0.0065 (0.006-0.025) | 0.006 (0.006-0.006) | 0.017 (0.006-0.043) | 0.369 |
| Lymphocyte subpopulation | |||||
| CD3+ count, /μL | 723-2737 | 801 (496-1154) | 1066 (804-1321) | 305 (198-525) | ＜0.001 |
| CD4+ count, /μL | 404-1612 | 461 (269-701) | 645 (461-794) | 184 (103-293) | ＜0.001 |
| CD8+ count, /μL | 220-1129 | 291 (164-424) | 366 (274-482) | 121 (54-197) | ＜0.001 |
| CD4/CD8 | 0.9-2.0 | 1.66 (1.27-2.20) | 1.66 (1.37-2.16) | 1.57 (1.10-2.36) | 0.342 |
| CD19+ count, /μL | 80-616 | 155 (105-229) | 190 (139-268) | 91 (54-139) | ＜0.001 |
| CD16+ 56+ count, /μL | 84-724 | 127 (81-209) | 144 (93-231) | 105 (66-168) | ＜0.001 |
| Humoral immune function (189)b | |||||
| IgG, g/L | 8-16 | 12.1 (10.0-14.7) | 11.6 (9.9-13.8) | 13.4 (10.5-16.5) | 0.024 |
| IgM, g/L | 0.4-3.45 | 1.04 (0.75-1.34) | 1.11 (0.86-1.38) | 0.94 (0.66-1.22) | 0.009 |
| IgA, g/L | 0.76-3.9 | 1.91 (1.45-2.53) | 1.84 (1.45-2.44) | 2.10 (1.43-2.85) | 0.281 |
| IgE, IU/mL | <100 | 23.5 (17.3-80.8) | 21.9 (17.3-84.3) | 30.85 (17.3-68.9) | 0.707 |
| Complement C3, g/L | 0.81-1.6 | 0.85 (0.74-0.98) | 0.82 (0.73-0.96) | 0.91 (0.78-1.00) | 0.045 |
| Complement C4, g/L | 0.1-0.4 | 0.24 (0.18-0.31) | 0.23 (0.17-0.30) | 0.26 (0.20-0.32) | 0.275 |
| Cytokines (28)c | |||||
| IL-2, pg/ml | ≤11.4 | 3.65 (3.42-4.06) | 3.55 (3.38-3.65) | 4.06 (3.28-4.09) | 0.249 |
| IL-4, pg/ml | ≤12.9 | 3.95 (3.74-4.36) | 3.75 (3.70-3.85) | 4.30 (4.01-4.60) | 0.005 |
| IL-5, pg/ml | ≤20.0 | 2.33 (2.22-2.56) | 2.39 (2.30-3.05) | 2.27 (2.12-2.35) | 0.062 |
| IL-6, pg/ml | ≤20.0 | 14.1 (7.5-14.0) | 14.0 (7.2-15.3) | 14.3 (7.8-11.6) | 0.953 |
| IL-10, pg/ml | ≤5.9 | 6.48 (6.07-7.65) | 6.37 (5.71-6.67) | 7.25 (6.20-8.05) | 0.147 |
| TNF, pg/ml | ≤5.5 | 2.72 (2.47-3.00) | 2.50 (2.44-2.73) | 2.98 (2.63-3.11) | 0.004 |
| γ-interferon, pg/ml | ≤18 | 3.8 (3.57-4.46) | 3.93 (3.51-4.61) | 3.8 (3.8-3.93) | 0.334 |
Abbreviations, IQR, interquartile range.
a
The number of patients whose data of Hypersensitive troponin I was available were 86, including 37 non-severe patients and 49 severe patients.
b
The number of patients whose data of humoral immune function was available were 189, including 125 non-severe patients and 64 severe patients.
c
The number of patients whose data of cytokines was available were 28, including 12 non-severe patients and 16 severe patients.