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. 2020 Apr 13;84:106495. doi: 10.1016/j.intimp.2020.106495

Fig. 5.

Fig. 5

In vitro generation of cytotoxic T lymphocytes (CTLs) is improved by DCs exposed to lysates of HCT-116 previously treated with 5-FU + CQ. Mean fluorescence intensity (MFI) of proliferating CD8+ cells (A) of four healthy donors at individual effector:target ratios (3.25:1, 7.5:1, and 15:1). These lymphocytes showed higher expression levels of the cytotoxicity markers perforin (MFI 15:1 ratio, 5-FU + CQ > WT (p < 0.05)) and granzyme B (MFI 7.5:1 ratio, 5-FU + CQ > WT (p < 0.05); MFI 15:1 ratio, 5-FU + CQ > WT (p < 0.05)) compared to the WT control group.