Table 2.

Fold change expression of selected genes by tumor cells, comparing untreated cells (WT) with those treated with CQ, 5FU or CQ + 5FU.

Gene functions	Gene name	WT vs CQ	WT vs 5-FU	WT vs 5-FU + CQ
Autophagy-	ATG12	1.7	3.2	7.1
	ATG5	1.9	4.5	6.4
	MAP1LC3B	1.8	2.3	5.7
	ULK1	1.2	2.4	5.2
	SQSTM1	2.1	1.9	4.8
	BECN1	0.8	5.8	2.5
	BNIP3	−4.36	−1.36	−4.11
	BNIP3L	−4.06	−1.2	−3.85
Cell adhesion	CEACAM5	−0.9	1.5	8.4
	CEACAM6	−1.3	2.4	6.5
	CEACAM7	−2.1	1.7	5.2
	CEACAM1	−1.2	2.1	5.7
	HES1	−3.16	−0.5	−7.1
	FOSL2	−4.72	−0.72	−3.6
	NDRG1	−10.43	−1.43	−6.11
Catalytic activity	PIK3R2	−1.2	−3.97	−4.2
	PGK1	−2.59	−0.2	−2.59
	LOXL2	−4.8	−0.9	−2.85
	PGK1	−2.59	−0.2	−2.59
	ALDOC	−8.14	−1.14	−7.52
	ANGPTL4	−6.25	−1.25	−5.93
Structural molecule activity	LAMB3	−4.26	−0.76	−3.59
Heat shock proteins and HMGBs	HMGB1	1.02	1.9	1.12
	HMGB2	0.98	1.87	1.05
	HMGB3	0.2	0.5	0.347
	DNAJB1 (HSP40)	1.17	1.5	0.85
	HSP1A (HSP70)	2.67	2.82	3.38
	HSP90AB1 (HSP90)	1.45	2.97	1.52
Oxidoreductase	P4HA1	−6.53	−1.1	−6.89
RNA binding	PCBP1	1.2	2.86	8.26