Skip to main content
. Author manuscript; available in PMC: 2020 Apr 13.
Published in final edited form as: Chemistry. 2018 Aug 10;24(50):13278–13289. doi: 10.1002/chem.201802038

Table 3.

Frequencies of Guanine Adducts upon Replacement of the Non-Alkylated Guanine by Inosine at CpG, GpC and GpG steps in oligonucleotides 17, 18, and 19.

Frequency (%) of the major adducts detected
Oligonucleotides 2a 2b 2a + 2b log(2b/2a)
17 5’-ATTATTGCTATT
3’-TAATAACGATAA
0.36 (±0.04) 4.04 (±0.3) 4.41 1.05
5’-ATTATTGCTATT
3’-TAATAACIATAA
0.52 (±0.05) 2.13 (±0.19) 2.64 0.61
19 5’ATTATTCGTATT
3’-TAATAAGCATAA
1.17 (±0.03) 0.1 (±0.01) 1.27 −1.05
5’-ATTATTCGTATT
3’-TAATAAICATAA
0.94 (±0.04) 0.64 (±0.05) 1.58 −0.18
18 5’-ATTATTGGTATT
3’-TAATAACCATAA
0.43 (±0.03) 0.18 (±0.005) 0.6 −0.38
5’-ATTATTIGTATT
3’-TAATAACCATAA
0.40 (±0.04) 1.27 (±0.2) 1.68 0.50
5’-ATTATTGITATT
3’-TAATAACCATAA
0.53 (±0.04) 0.40 (±0.012) 0.93 −0.11