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Inhibitory effect of 4a on LPS-mediated (a) TNF-α and (b) IL-6 synthesis in RAW264.7 cells, which were pretreated with 4a (10, 20, 30 μM) or HSS (20 μM) for 2 h before the LPS stimulation (1 μg/mL) for 4 h. The data are expressed as the mean ± SD (n = 3): (##) p < 0.01, (###) p < 0.001, relative to the control group; (∗) p < 0.05, (∗∗) p < 0.01, relative to LPS-stimulated group; HSS, hydrocortisone sodium succinate.
