Table 1. cAbl, hERG, and CYP3A4 Activities as Well as Metabolic Stability and CC₅₀ Values for Target Compounds.

	cAbl IC50 (nM)	hERG IC50 (μM)	CYP3A4 IC50 (μM)	Mouse Liver Microsomes t1/2 (min)	Human Liver Microsomes t1/2 (min)	THLE-3 CC50 (μM)	HEK293 CC50 (μM)
1	0.30	0.34	11.7
2	0.39	0.10	13.4
3	0.65	0.08	13.5
4	9.96	5.02	5.58	10.95	26.87	17.0	14.5
5	8.31	12.1	7.28	16.78	39.84	>50.0	>50.0
6	>30	0.78	4.61	26.45	157.53
Nilotinib	5.56	0.45	0.58	7.89	7.89
Ponatinib	0.31	0.77	11.4	31.94	182.4