Table 2. % Activity Remaining and IC₅₀ Values of Nilotinib, Ponatinib, 4, and 5 for Selected Kinases.

	% Activity Remaining		% Activity Remaining and [IC50 (μM)]
kinase	Nilotinib	Ponatinib	4	5
ABL	2	1	8 [0.0031]	11 [0.0013]
DDR2	4	3	70 [>20]	14 [0.2862]
PDGFRa	56	25	10 [0.0021]	16 [0.0020]
Src	74	11	23 [0.7097]	15 [0.4313]
EPHB2	25	2	2 [0.0932]	1 [0.0708]
EPHB3	52	1	6 [0.0505]	5 [0.0195]
Lck	37	29	22 [0.0908]	17 [0.0261]
EPHA4	23	4	6 [0.1381]	2 [0.0846]
NEK6	97	52	45 [3.3060]	9 [5.3500]
VEGFR	75	28	14 [0.0336]	13 [0.0448]
MAP4K3	107	2	62 [>20]	14 [0.2404]