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. 2020 Feb 12;11(4):506–513. doi: 10.1021/acsmedchemlett.9b00621

Table 3. DMPK Profile of Compound 39.

  in vitro
 in vivoa
  % free plasma BPR Hep Clp (L/h/kg) Cl (L/h/kg) Vss (L/kg) T1/2 (hr) F (%)b
rat 11.8 0.83 1.4 1.77 2.5 3.7 60
dog 38.5 2.19 0.28 0.33 1.6 5.3 100
monkey 32.2 2.38 0.28 0.58 1.3 2.3 100
human 20.4 1.84 0.05        
a

Intravenous administration at 1.0 mg/kg. Oral administration at 5.0 mg/kg.

b

F = oral bioavailability