Table 4. Biological Profile of Compound 39.

cell type	assay	stim	readout	EC50 ± SD (nM)
B-cells	signaling	αIgM	pBLNK-Y96	24
			p-Btk-Y223	26
			p-Akt-S473	34
			pERK-T202/Y204	37
			pMEK-s217/s221	51
	activation		CD69	112 ± 10
			CD86	164 ± 16
	proliferation	αIgM/αCD40	EdU incorporation	108 ± 55
T-cells	proliferation	αCD3/αCD28	EdU incorporation	1305 ± 425
macrophages	cytokine release	immune complex	TNFα	180
			IL-1β	90
			IL-6	700
basophilsa	activation	αIgE	CD63	73 ± 20

^aHuman whole blood.