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| Compound | 11a (mouse) | 15a (mouse) | 15aa (rat) |
|---|---|---|---|
| AUC,n0-inf(i.v. kg·h/L) | 4.13 | 1.66 | 3.92 |
| C0orCmax(i.v.mg/L) | 34.59 | 18.83 | 21.22 |
| CL (i.v.mL/min/kg) | 4.0 | 10.0 | 4.2 |
| t1/2(i.v. h) | 3.26 | 0.62 | 32.71 |
| Vss (i.v.L/kg) | 0.2 | 0.16 | 3.04 |
| MRT (i.v. h) | 0.81 | 0.26 | 11.91 |
| F (p.o. %) | 7 | <1 | 4 |
