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In vivo IL-1β inhibition of compounds 15, 29, and 34 in C57 mice (n = 6 animals/group; female C57 mice; po 10 mg/kg; formulation, 1% Tween 80 and 99% methyl cellulose (0.5%); ***P < 0.001 versus control, **P < 0.01 versus control; error bar indicates SEM).
