. 2020 Feb 27;11(4):414–418. doi: 10.1021/acsmedchemlett.9b00433

Table 2. Modifications on Left-Hand Side of N-Cyano-sulfoximineurea Derivatives: In Vitro Activity and Pharmacokinetics Properties^a of 15, 29–34.

Compounds dosed 1 mg/kg iv and 3 mg/kg po.

PO: Mouse PK data is mean data because of composite study design, n = 3/time point. Formulation: PO, 1% Tween 80 + 99% (0.5%) methyl cellulose in water; IV, 5% NMP + 5% solutol +90% normal saline.

Calculated from Schrödinger Release 2018-3: QikProp, Schrödinger, LLC, New York, NY, 2018. NC: Not calculated.

Table 2. Modifications on Left-Hand Side of N-Cyano-sulfoximineurea Derivatives: In Vitro Activity and Pharmacokinetics Propertiesa of 15, 29–34.

Table 2. Modifications on Left-Hand Side of N-Cyano-sulfoximineurea Derivatives: In Vitro Activity and Pharmacokinetics Properties^a of 15, 29–34.