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(A) Top1 inhibitory activity assay of evodiamine borate derivatives at 500, 250, and 125 μM, respectively. (B) Top1 inhibitory activity assay of compounds 13a and 15a ranging from 27.9 to 250 μM. (C) Top2 inhibitory activity assay of evodiamine borate derivatives at 200, 100, and 50 μM, respectively. (D) Top2 inhibitory activity assay of compounds 13a and 15a ranging from 25 to 200 μM.
