. 2020 Mar 3;11(4):514–520. doi: 10.1021/acsmedchemlett.9b00629

Table 1. Inhibitory Activity of Selected Hits against ZIKV, WNV, and DENV2 Protease^a.

Compound	ZIKV^Pro K_i [μM]	WNV^Pro K_i [μM]	DENV2^Pro K_i [μM]
397_2	11.5 ± 0.5	7.4 ± 1.3	n.d.
397_6	n.d.	n.d.	n.d.
397_12	n.d.	n.d.	n.d.
427_1	2.3 ± 0.4	25.5 ± 11.8	0.09 ± 0.03
427_2	n.d.	n.d.	n.d.

K_i values were determined for the ligands with inhibition cutoff below 50 μM. n.d.: not determined.

Table 1. Inhibitory Activity of Selected Hits against ZIKV, WNV, and DENV2 Proteasea.