Table 1. IC50 ± Standard Deviation, Retention Times,a and cLogD7.0 of Tested Compounds.
| compd | IC50 ± standard deviation (nM)b | retention time (min) | cLogD7.0c |
|---|---|---|---|
| 1b | 29d | n.d. | 3.56 |
| 1c | 63d | n.d. | –3.81 |
| 3 | >25000 | 5.184 | –0.39 |
| 4 | 9300 ± 560 | 5.008 | –3.15 |
| 5 | >25000 | 5.254 | 0.25 |
| 6 | 13000 ± 3700 | 5.071 | –3.30 |
| 11 | 1500 ± 18 | 6.737 | 2.07 |
| 12 | 678 ± 29 | 5.886 | 0.13 |
| 15 | 3000 ± 120 | 6.072 | 3.07 |
| 16 | >25000 | 6.184 | 4.08 |
| 19 | 189 ± 9 | 5.995 | 1.19 |
| 20 | 14000 ± 1060 | 6.312 | 2.08 |
| 21 | 126 ± 20 | 5.910 | 0.44 |
| 22 | 151 ± 20 | 5.995 | 1.19 |
| 23 | 241 ± 8 | 5.995 | 1.19 |
a
See Supporting Information for HPLC method.
b
Standard deviation of two independent experiments.
c
Values calculated with ChemAxon’s LogD Predictor.30
d
Values were taken from Jain et al., and compounds were run in parallel as standards in the FA assay.20