Table 6. Dose–Response Summary for Mouse PK/PD Study of Compound 20.
20 |
TRP |
|||
---|---|---|---|---|
dosea | AUC∞ (μM × h) | Cmax (μM) | AUC0–6h (μM × h) | Cmax (μM) |
0 | 570 | 340 | ||
10 | 5.0 | 4.1 | 680 | 420 |
30 | 35 | 21.2 | 1,120 | 560 |
100 | 210 | 70 | 1,980 | 540 |
mg × kg–1 compound 20.