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. 2020 Mar 4;11(4):541–549. doi: 10.1021/acsmedchemlett.0c00004

Table 6. Dose–Response Summary for Mouse PK/PD Study of Compound 20.

  20
TRP
dosea AUC (μM × h) Cmax (μM) AUC0–6h (μM × h) Cmax (μM)
0     570 340
10 5.0 4.1 680 420
30 35 21.2 1,120 560
100 210 70 1,980 540
a

mg × kg–1 compound 20.