Table 3. PK Parameters and Brain Tissue Exposure^a.

									brain/plasma ratio
compd	route	dose	CL (mL/min/kg)	VSS (L/kg)	t1/2 (h)	AUC (h·μM)	Cmax (μM)	F (%)	AUC	Cmax
1 (WF-47-JS03)	iv	5	51	13	3.9	3.2	1.1
	pob	20			11	12	0.73	94	0.94	0.81
9 (YA-14-WJ39)	iv	5	54	7.8	1.8	2.6	1.6
	po	20			2.5	6.8	0.88	64	0.15	0.13
10 (SC-89-VU43)	iv	2	19	5.1	3.7	2.8	0.94
	po	10			3.7	8.7	0.82	62	NA	NA
11	iv	2	110	11	1.6	0.49	0.45
	po	10			2.2	0.34	0.10	14	NA	NA

^aPK studies run in Balb/c mice.

^bHCl salt used for dosing.