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. 2020 Mar 17;36:100974. doi: 10.1016/j.molmet.2020.100974

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Remodeling of the fatty acid profiles of the phospholipidomes of the testes of the fads2−/− mice on the sustained ω6/ω6-PUFA diet after a feeding period of 2 months started after weaning at p21. Fatty acid patterns of the phospholipid classes of the testes of the control and fads2−/− mice on (A) nd, (B) AA, (C) DHA, and (D) AA/DHA diets. The dynamics of PUFA replenishment of the PL classes, the surrogate function of ω6-20:3^5,11,14 in nd-fads2−/− testes, and the modifications in VLC-PUFA substituted ceramide species in the nd-fads2−/− testes on the respective diets are highlighted in the boxes.