Table 5.
Vertebrate sialic acid-specific lectins [18], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348]
| Names (synonyms) | Expression (source)a | Binding specificity |
|---|---|---|
| E-selectin (ELAM-1, CD62E) | Activated endothelium | sialyl Lex, sialyl Lea |
| L-selectin (MEL 14 antigen, CD62L) | Leucocyte | 6′-sulfo sialyl Lex, heparan sulfate |
| P-sclectin (GMP 140, PADGEM. CD62P) | Activated endothelium, platelet | sialyl Lex, sialyl Lea, heparan sulfate (HS) |
| Siglecs | ||
| Siglec-1 (sialoadhesin) | Macrophage | Neu5Acα2–3Gal > Neu5Acα2 – 6Cal |
| Siglec-2 (CD22) | B-cell | Siaα2–6Gal |
| Siglec-3 (CD33) | Myeloid precursor, Mobc | Siaα2–6Gal ≥ 2 Siaα2–3Gal |
| Siglec-4 (MAG) | Glial cells | Neu5Acα2–3Gal on complex gangliosides |
| Siglec-5 | Mo, Gr | Siaα2–6Gal ≈ Sioα2–3Gal, Neu5Acα2–8 |
| Siglec-6 (OB-BP1) | Placenta, B-cell | Siaα2–6Gal NAc |
| Siglec-7 (AIRM-1) | NK cells, Mo, Gr | Siaα2–6Gal ≈ Siaα2–3Cal (3-Ig isoform), Siaα2–6Gal (2-Ig isoform) |
| Siglec-8 | Eosinophil, basophil | Siaα2–3Gal ≥ Siaα2–6Gal |
| Siglec-9 | Mo, Gr | Siaα2–6Gal ≈ Siaα2–3Gal |
| Siglec-10 | B-cell | Siaα2–6Gal ≈ Siaα2–3Gal |
| Siglec-11 | Fibroblasts | Neu5Acα2–8Neu5Ac |
| Others | ||
| Complement factor H | Blood | Sia; C7–C9 side chain is a part of epitope |
| CD83 | Dendritic cell | Sia |
| LI | Mouse neuron | Neu5Acα2–3 (on CD24) |
| Interleukin-1α | Blood | Neu5Acα2–3Galβ1–4GlcNAc, biantennary |
| Interleukin-1β | Blood | Neu5Acα2–3Galβ1-Cer (GM4) |
| lnterleukin-2 | Blood | GD1b |
| Interleukin-4 | Blood | Neu5Ac1,7lactone |
| Interleukin-7 | Blood | Neu5Acα2–6GalNAc |
| Laminin | Extracellular matrix | Neu5Acα2–3Galβ1–4GlcNAc (α2–3 > α2–6) |
| Sialic acid-binding protein | Endometrium | Neu5Gc > Neu5Ac |
| Sarcolectin | Placenta | Neu5Ac, Neu5Gc |
| Calreticulin | Ovine placenta | Neu5Gc > Neu5Ac, prefer O-acetyl |
| Sialic acid-binding protein | Rat uterus | Sia |
| Calcyclin | Bovine heart | Neu5Gc |
| Sialic acid-binding protein | Frog egg | Sia |
| Ganglioside binding protein⁎ | Rat brain myelin | Gangliosides (CT1b, CQ1b, GD1b) |
| Hemagglutinin⁎ | Rat brain | Neu5Ac, Neu5Gc |
a
Expression (source) is in human, unless otherwise stated.
b
Mo, monocyte; Gr, granulocyte.
c
Most of the proteins are cloned and/or purified to homogeneity, except for the entities marked with an asterisk (*).
Adapted with permission and updation from Angata T, Varki A. Chemical diversity in the sialic acids and related α-keto acids: an evolutionary perspective. Chem Rev 2002;102:439–469.