TABLE 1.
UTRICLES | Number of hair cells per organ (mean ±SD) | ||||
---|---|---|---|---|---|
Group | tdTom+ HCII | tdTom+ HCI | tdTom− HCII | tdTom− HCI | N (mice) |
WT 3w | 206 ±32 | 0±0 | 83 ±53 | 236 ±153 | 4 |
WT 12w | 404 ±47 | 0±0 | 74 ±38 | 217 ±23 | 3 |
CKO 3w | 13 ±6 | 0±1 | 99 ±40 | 259 ±139 | 3 |
CKO 12w | 20 ±7 | 0±0 | 61 ±13 | 101 ±23 | 3 |
Effect | Two-way ANOVA p Value | ||||
Time post-DT | 0.0001 | 0.3018 | 0.1876 | ||
Atoh1 deletion | <0.0001 | 0.3018 | 0.4692 | ||
SACCULES | Numbers of hair cells per 10,000 μm^2 (mean ±SD) | ||||
Group | tdTom+ HCII | tdTom+ HCI | tdTom− HCII | tdTom− HCI | N (mice) |
WT 3w | 4.82 ±2.01 | 0.0 ±0.0 | 2.78 ±0.90 | 7.26 ±4.39 | 3 |
CKO 3w | 0.33 ±0.14 | 0.0 ±0.0 | 4.64 ±2.44 | 7.53 ±1.66 | 3 |
t-test p value | 0.0181 | N/A | 0.2827 | 0.9254 | |
LAT AMPULLAE | Numbers of hair cells per 10,000 μm^2 (mean ±SD) | ||||
Group | tdTom+ HCII | tdTom+ HCI | tdTom− HCII | tdTom− HCI | N (mice) |
WT 3w | 7.05 ±1.36 | 0.0 ±0.0 | 1.39± 1.37 | 8.53 ±6.18 | 3 |
CKO 3w | 0.07 ±0.13 | 0.0 ±0.0 | 1.53 ±0.07 | 5.99 ±2.27 | 3 |
t-test p value | 0.0009 | N/A | 0.8626 | 0.5417 |