Table 3.

Comparison of minor allele frequencies obtained in this study and those conducted among in Spain, Puerto Rico, Brazil, Colombia, and African American population (http://www.ensembl.org/Homo_sapiens/Info/Index; modified from Visser et al., 2005; Kocael et al., 2019).

Polymorphic variant	Chile (this study)	Spain	Puerto Rico	Colombia	African-American	European	East Asia	Effect on VKA dose
VKORC1 (rs9923231)	0.467	0.360	0.389	0.420	0.054	0.388	0.885	Decrease
VKORC1 (rs7294)	0.311	0.355	0.341	0.356	0.454	0.366	0.112	Increase
CYP2C9*2 (rs1799853)	0.081	0.140	0.139	0.122	0.008	0.124	0.001	Decrease
CYP2C9*3 (rs1057910)	0.041	0.084	0.043	0.064	0.002	0.073	0.034	Decrease
CYP4F2 (rs2108622)	0.229	0.355	0.288	0.282	0.082	0.290	0.214	Increase
ABCB1 (rs1045642)	0.627	0.463	0.428	0.441	0.150	0.518	0.398	Decrease
GGCx (rs11676382)	0.036	0.093	0.034	0.037	0.002	0.094	0.000	Decrease
APOE (rs429358)	0.092	0.140	0.106	0.154	0.268	0.155	0.086	Decrease