Table 4.
Linear regression including genetic factors and clinical variables in a single model.
| N observed | 287 | ||||
|---|---|---|---|---|---|
| Model p-value* | < 0.0001 | ||||
| R 2 | 0.5147 | ||||
| Adjusted R2 | 0.4999 | ||||
| Variable | Coefficient | Standard error | p-value* | CI (95%) | |
| Sex (men) | 0.1668786 | 0.0407027 | 0.000 | 0.0867528 | 0.2470045 |
| Age | -0.008101 | 0.001472 | 0.000 | -0.0109987 | -0.0052034 |
| Initial INR | -0.0547186 | 0.0168253 | 0.001 | -0.0878404 | -0.0215969 |
| BMI | 0.0125554 | 0.0035861 | 0.001 | 0.0054959 | 0.0196149 |
| CYP2C9*2 (rs1799853) | |||||
| *1/*2 | -0.1067491 | 0.0538426 | 0.048 | -0.2127418 | -0.0007565 |
| CYP2C9*3 (rs1057910) | |||||
| *1/*3 | -0.3227895 | 0.0806461 | 0.000 | -0.4815465 | -0.1640324 |
| *3/*3 | -0.7465348 | 0.2416193 | 0.002 | -1.222178 | -0.2708915 |
| VKORC1 (rs9923231) | |||||
| G/A | -0.2704925 | 0.0479039 | 0.000 | -0.3647945 | -0.1761906 |
| A/A | -0.7008277 | 0.0583063 | 0.000 | -0.8156074 | -0.586048 |
| Constant | 3.080551 | 0.1622701 | 0.000 | 2.761112 | 3.33999 |
*P < 0.05 is considered as statistically significant.
BMI, body mass index; INR, international normalized ratio.