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. Author manuscript; available in PMC: 2020 Apr 13.
Published in final edited form as: J Alzheimers Dis. 2019;72(2):467–478. doi: 10.3233/JAD-190779

Fig. 2.

Fig. 2.

MK0677 treatment significantly increased neurogenesis in 5xFAD mice. A) 5xFAD mice presented increased DCX+ cells after MK0677 treatment. Two-way ANOVA followed by Bonferroni post hoc analysis. t = 3.541, *p < 0.05 nonTg saline versus 5xFAD saline; t = 0.5837, NS, no significant difference between nonTg saline and nonTg MK0677 treatment groups; t = 3.172; *p < 0.05 5xFAD saline versus 5xFAD MK0677; t = 3.223, *p < 0.05 nonTg saline versus Ghsr null saline; t = 0.04955; NS, no difference between Ghsr null saline and MK0677 treatment groups. n = 4 mice per group. B) Representative images for neurogenesis, DCX+ cells represent newly generated neurons (red), nuclei were labeled with DAPI (blue). Scale bar = 40 μm.