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Effect of compound 14 on icilin-induced WDS in ICR (CD1) mice. Compound or vehicle was administered 30 min before icilin injection. Gabapentin (25 mg/kg) was administered 1 h before icilin injection. After i.p. injection of icilin (10 mg/kg), the number of wet dog shakes (WDS) was counted over 30 min. Data are given as mean ± SEM (n = 6). Two-way ANOVA with Bonferroni post hoc test. **P < 0.01.
