Figure 11.

Effect of compound 14 on Oxaliplatin (OXP)-induced cold allodynia in male C57 mice. Mice were given three i.p. injection of OXP (6 mg/kg) or the vehicle (saline and a 5% mannitol solution, black line (control)) on alternate days. At day 7 after administration, cold allodynia was evaluated by the acetone test. Time-course of cold allodynia without compound injection (green line) and injection of compound 14 at 0.1 μg (blue line) or at 1.0 μg (red line). Data are given as mean ± SEM n = 6. One-way ANOVA with Dunnett’s post hoc test. *P < 0.05; ***P < 0.001; ****P < 0.0001.