Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding mode of 5 and 7 in hTRPM8. Analogues 5 and 7 are shown as yellow and orange sticks, respectively. Important residues are shown as sticks. Individual helices are colored as follows: S1 (blue), S2 (faded green), S4 (yellow green), and TRP helix (red). The Ca2+ ion (green) is shown in CPK representation. Our hTRPM8 homology model was constructed using the cryo-electron microscopy (cryo-EM) structure of TRPM8FA (PDB 6BPQ) as a template.
